Anabolic Pump is a pretty unique product from USP Labs, makers of the once insanely popular Jack3d. AP is essentially a glucose control supplement with the tagline “Don’t Eat Carbs Without It!”…FIND IT HERE
Phellodendron, also known as Cork Tree, is a type of tree native to parts of Asia. While not much research exists regarding the possible health benefits of the plant as a whole, one active compound has been identified and studied fairly thoroughly. Berberine, an alkaloid that is also found in several other herbs, has been shown to act as a hypoglycemic agent (meaning it can significantly lower blood glucose levels), as well as increase muscle glucose uptake in rats. So, how does berberine work exactly?
Well, the mechanism of action lies in berberine’s ability to activate AMPK, a fuel-sensing enzyme present in all mammals that is generally activated by exercise. During exercise, AMPK is activated to some degree, which stimulates glucose uptake and fatty acid oxidation, while simultaneously decreasing protein and lipid synthesis.
A 2007 study, published in the American Journal of Physiology: Endocrinology and Metabolism, concluded that berberine stimulated glycolysis (the conversion of glucose to pyruvate, the energy from which is used to form ATP) in rats. While more studies are needed to determine if this exact mechanism of action holds true in human subjects, the results are certainly the same. Berberine has the ability to regulate blood glucose, thus making it a fine addition to a glucose-regulating product such as AP by USP Labs.
Lagerstroemia Speciosia (A.K.A. Crape Mertle and Banaba) is flowering tree native to the Philippines. The active ingredient in Lagerstroemia Speciosia extract is called corosolic acid, which also has powerful glucose lowering properties.
A 2006 study, published in Diabetes Research and Clinical Practice concluded that 10 mg of corosolic acid, taken orally, resulted in a significant lowering of blood glucose levels about 90 minutes after ingestion. While this was the first study proving the efficacy of corosolic acid supplementation on blood glucose levels in humans, several studies have been done in mice with the same results.
Corosolic acid has been shown again and again to increase insulin sensitivity in mice via an increase in glucose transporter type 4 (GLUT4), the protein responsible for glucose transport into the cell, translocation in muscle. While more studies are always a good thing, there really is no shortage of scientific research on this compound. Furthermore, all the research, whether done on animal or human subjects, has yielded the same results: corosolic acid is a highly effective blood glucose regulator.
THE BOTTOM LINE
We are actually quite impressed with USP’s Anabolic Pump formula. While the blend only contains two ingredients, both of these ingredients have a massive amount of scientific research backing them, and there is really no doubt about the effectiveness of the product for people who actually need it. Unfortunately, if you are already at 10% body fat, looking to get down to 7%, this product may not get you there. In otherwords, if you already have relatively good insulin sensitivity, regulating your blood sugar will not make you super shredded. However, we’re not saying you have to be diabetic to benefit from this product. Anyone who is overweight as a result of insulin resistance may derive great benefit from supplementing with AP. The products two ingredients couldn’t be more scientifically validated, and for that, we applaud USP.
- in, Jun, Huili Xing, and Jianping Ye. “Efficacy of berberine in patients with type 2 diabetes mellitus.” Metabolism 57.5 (2008): 712-717.
- Kong, Weijia, et al. “Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.” Nature medicine 10.12 (2004): 1344-1351.
- Canale, Robert E., et al. “A blend of Phellodendron and Crape Myrtle improves glucose tolerance in exercise-trained men.” Nutrition and Metabolic Insights 4 (2011): 39-47.
- Judy, William V., et al. “Antidiabetic activity of a standardized extract (Glucosol™) from< i> Lagerstroemia speciosa leaves in Type II diabetics: A dose-dependence study.” Journal of Ethnopharmacology 87.1 (2003): 115-117.
- Fukushima, M., et al. “Effect of corosolic acid on postchallenge plasma glucose levels.” Diabetes research and clinical practice 73.2 (2006): 174-177.
- Shi, Lei, et al. “Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.” European journal of pharmacology 584.1 (2008): 21-29.
- Miura, Toshihiro, et al. “Antidiabetic effects of corosolic acid in KK-Ay diabetic mice.” Biological and Pharmaceutical Bulletin 29.3 (2006): 585-587.
- Takagi, Satoshi, et al. “Effect of corosolic acid on the hydrolysis of disaccharides.” Journal of nutritional science and vitaminology 54.3 (2008): 266-268.
- Cheng, Zhe, et al. “Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.” Biochimica et Biophysica Acta (BBA)-General Subjects 1760.11 (2006): 1682-1689.