Adipo-X PM is Axis Labs’ attempt at a night-time fat-burner. Unfortunately, like most products that claim to help you burn fat while you sleep, the science doesn’t quite add up.
Carnitine is an amino acid that is heavily involved with the metabolism of fat for energy. It is required for the proper transport of fatty acids in the mitochondria, where they are oxidized (burned) for energy. Carnitine deficiency has been shown to hinder fat-burning capacity, but it is also commonly alleged (by supplement companies) that excess Carnitine intake can burn excess fat. Given this relationship, several studies have been conducted specifically to investigate the effects of Carnitine on fatty acid oxidation and bodyweight.
A 2002 study, published in “Metabolism”, found that Carnitine supplementation (1g/day) increased fatty acid oxidation rates in humans without Carnitine deficiency.
A 2004 study from the same journal found that L-Carnitine supplementation (3g/day) increased fatty acid oxidation in overweight subjects while having no effect on protein synthesis or breakdown.
However, a 2005 study, published in the “International Journal for Vitamin and Nutrition Research”, found that Carnitine supplementation failed to influence weight-loss in rats. The results of this study were in-line with an earlier (2002) study in which L-Carnitine supplementation (4g/day) failed to influence fat mass, body mass, or resting lipid utilization in moderately obese women. A more recent (2010) study found that Carnitine supplementation did favorably influence fatty acid utilization in rats, though this study did not measure fat mass post-supplementation.
Ultimately, Carnitine does possess the mechanisms by which it “should” burn fat (via increased utilization of fatty acids), though supplementation has failed to result in fat-loss in animals and humans. To be fair, Carnitine has not been extensively studied when paried with high intensity exercise, so it is possible that Carnitine may increase the burning of fat only when warranted to by exercise. However, since Adipo-X PM is a night-time formula, users would not be pairing Carnitine with exercise either. Furthermore, the low 500mg dose of Carnitine makes Adipo-X PM even less likely to influence body fat in any way
Despite the popularity of Raspberry Ketone, it has never actually demonstrated any efficacy for weight-loss in actual humans and, even in rat studies, has produced lackluster results using massive concentrations. A 2010 in vitro study found that treatment with Raspberry Ketone increased fatty acid oxidation and lipolysis in adipocytes (fat cells). However, the amount/concentration of RK used in this study is beyond what could practically be consumed in oral supplement form.
A 2005 study, seeking to determine the weight loss effects of raspberry ketone on rats fed a high fat diet, noted dose dependent anti-obesity effects using doses of .5-4 grams/kg. This would roughly correspond to a 150lb person consuming 34-130 grams daily, a highly impractical dose. In a 2012 study, similar effects were observed in rats, though this time with a focus on fat accumulation in the liver resulting from a high fat diet.
The only human study that exists grouped Raspberry Ketone in with several other popular weight-loss ingredients so the effects cannot be attributed to raspberry ketones alone. On a molecular level, Raspberry Ketone certainly demonstrates anti-obesity effects, but the doses used to achieve these effects are far more than what the average human could practically consume. Adipo-X PM contains 100mg of Raspberry Ketone per serving, a negligible dose compared to what has been used in in vitro studies to induce lipolysis. Even at 10 times that dose, the benefits would be questionable.
THE BOTTOM LINE:
The short answer is: not very well. The two main ingredients in Adipo-X PM, L-Carnitine and Raspberry Ketone, are far from proven fat-burners. L-Carnitine is certainly the more promising of the two, but the low dose found in Adipo-X PM makes it more or less useless. Axis Labs makes some seemingly incredible claims about their night-time fat-burner, but none of these claims have been substantiated by actual research. Ultimately, it is highly unlikely (if not impossible) that consuming Adipo-X before bed will burn fat while you sleep.
- Wutzke, Klaus D., and Henrik Lorenz. “The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects.”Metabolism 53.8 (2004): 1002-1006
- Seim, H., W. Kiess, and T. Richter. “Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults.” Metabolism 51.11 (2002): 1389-1391.
- Melton, S. A., et al. “L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.” International journal for vitamin and nutrition research 75.2 (2005): 156-160.
- Villani, Rudolph G., et al. “L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.”International journal of sport nutrition and exercise metabolism 10.2 (2000): 199-207.
- Karanth, Jyothsna, and K. Jeevaratnam. “Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity.” (2010).
- Wang, Lili, Xianjun Meng, and Fengqing Zhang. “Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.” Journal of medicinal food 15.5 (2012): 495-503.
- Park, Kyoung Sik. “Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.” Planta medica 76.15 (2010): 1654.
- Morimoto, Chie, et al. “Anti-obese action of raspberry ketone.” Life sciences77.2 (2005): 194-204.