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Xenadrine Core Review

Xenadrine Core is the most recent weight-loss supplement to be released by MuscleTech. The formula consists of both stimulant and non-stimulant ingredients, some of which we haven’t seen in any other weight-loss supplements (not necessarily a good thing)…

Xenadrine Core

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GREEN COFFEE EXTRACT

Green Coffee Bean Extract is generally standardized for Chlorogenic Acid content, and in the case of Xenadrine Core, it has been standardized to 45%. Chlorogenic Acid is the bioactive compound primarily responsible for the moderate weight-loss effects of Green Coffee observed in multiple studies.

A 2007 study, published in the “Journal of International Medical Research”, found that 12 weeks of Green Coffee (450-500mg Clorogenic Acid) supplementation resulted in a reduction (6.9%) in glucose absorption in healthy volunteers. Researchers also noted average weight loss of 5.4 kg (almost 12 lbs) over the duration of the study in the group receiving the Green Coffee Extract.

A 2006 study, this time using a smaller dose of Green Coffee Extract (yielding 140mg Chlorogenic Acid), found no such weight-loss benefit over a 12 week period. The obvious difference between these two studies is that the dose of the first (positive) study was about 3 times the dose used in the second (negative) study.

A 2012 study found that adults who consumed GCE (containing about 315mg Chlorogenic Acid) daily lost an average of 8kg with the average reduction in body fat being about 4%. However, this study has since been retracted for reasons unknown.

At higher doses (300mg+ daily), Green Coffee Extract can actually be quite effective as a non-stimulant weight loss agent. Xenadrine Core contains 200mg yielding 90mg of Chlorogenic Acid. In order to achieve noticeable benefits, we’d recommend 3-4 servings daily, though the stimulants present in the formula may get in the way of that for some individuals.

CAFFEINE ANHYDROUS

Caffeine tends to be a key ingredient in stimulant-based fat-burners because it can reliably increase Noradrenaline levels in individuals who are not highly tolerant. Upon release, Noradrenaline stimulates fat-burning while simultaneously increasing perceived energy and focus. Unfortunately, prolonged daily Caffeine consumption is generally associated with tolerance build-up, so the effects tend to degrade, rendering Caffeine more or less ineffective by itself. However, in combination with other stimulants (such as Higenamine), Caffeine can simply serve as a means of initiating the fat-burning process.

Xenadrine Core contains 150mg of Caffeine per serving, making multiple servings daily a viable option for those who aren’t too sensitive to Caffeine.

PHASEOLUS VULGARIS (WHITE KIDNEY BEAN)

Similar to Green Coffee Extract, White Kidney Bean is more of a calorie-blocker than a fat-burner, as it doesn’t actually target fat. Both in vitro, and in vivo studies have demonstrated the ability of White Kidney Bean to block the absorption of carbohydrates, when consumed simultaneously, via inhibition of amylase (a digestive enzyme responsible for the absorption of starches). By reducing carbohydrate absorption, WKB may mimic the effects of a calorie (carb) restricted diet to some degree. While all studies have confirmed that there is some carb-blocking effect, the degree tends to vary and the total weight loss effect is likely influenced by many individual factors.

A 2004 study from “Alternative Medicine Review” found that Phase 2 (a patented White Kidney Bean extract) supplementation resulted in a trend towards weight-loss, but did not achieve statistical significance.

A 2007 study, published in the “International Journal of Medical Sciences”, found that White Kidney Bean extract (445mg) was able to reduce bodyweight in slightly overweight human subjects.

Xenadrine Core contains an undisclosed amount of White Kidney Bean extract, though the addition of Green Coffee Extract may provide some additive benefit with regards to carb-blocking.

GARCINIA MANGOSTANA

Garcinia Mangostana, more commonly known as Mangosteen, is a tropical fruit which contains a wide variety of polyphenols including Xanthones. Although Mangosteen has been studied with regards to weight loss, these studies are confounded with the use of other ingredients so at this time it’s tough to gauge its true efficacy. Ultimately, while Mangosteen may possess certain pro-weight-loss mechanisms, we wouldn’t consider it a “key” ingredient in the context of Xendrine Core.

NELUMBO NUCIFERA (HIGENAMINE)

Nelumbo Nucifera (NN), sometimes referred to as Indian Lotus, is a flower which has been shown to induce lipolysis in vitro and in mice. The lipolytic effects of Nelumbo Nucifera are primarily attributed to the Higenamine content, although there are other compounds which may potentiate these effects. Higenamine is a Beta(2) Adrenergic Agonist (same mechanism as Ephedra), meaning it stimulates the Beta(2) Adrenergic Receptors which induce lipolysis (fat breakdown).

MuscleTech discloses that this particular Nelumbo Nucifera extract is standardized to contain 1% Higenamine, but since the total amount of NN remains a mystery, that doesn’t really mean much.

PERILLA FRUTESCENS

Perilla Frutescens is generally standardized for Rosmarinic Acid (also found in Rosemary) which has some general health implications which can mostly be attributed to its antioxidant properties. Unfortunately, there is no research regarding the weight-loss potential of Perilla Frutescens so, at the moment, it seems to be a “just because” ingredient, with MuscleTech making no direct claims one way or another.

CENTELLA ASIATICA (GOTU KOLA)

Centella asiatica, more commonly known as Gotu Kola, is an Ayurvedic herb which has traditionally been used as a cognitive enhancement agent. A 2005 study, published in “Physiology and Behavior”, found that mice given 200mg/kg of Gotu Kola extract daily for 15 days were able to better navigate in a series of maze test (enhanced memory). These results were replicated in a 2007 study from “Neurosciences”.

MuscleTech claims Gotu Kola helps “enhance the sensory” aspect of Xenadrine Core, and the preliminary research supports this claim, although the degree of efficacy in humans remains unclear.

CARAWAY SEED

Caraway Seed contains, among other things, the polyphenol Carvacrol. A 2012 study, published in “The Journal of Nutritional Biochemistry”, found that Carvacrol administration was able to negate weight gain in mice fed a high-fat diet. Although the exact mechanism is unknown, it does appear that Carvacrol possesses some inherent anti-obesity properties. Human studies are certainly needed before drawing any solid conclusions, but the preliminary research supports MuscleTech’s use of Caraway Seed in the Xenadrine Core formula.

THE BOTTOM LINE

Xenadrine Core does contain effective enough doses of certain weight-loss ingredients (GCE, Caffeine, Higenamine) to induce noticeable weight-loss over-time, but there are also some questionable additions which may not do much in the way of enhancing the overall efficacy of the formula. This is certainly a “multiple servings” type formula, but given a price of about 35 cents per serving, multiple servings isn’t much of an issue.

REFERENCES
  1. Cho, Soomin, et al. “Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet.” The Journal of nutritional biochemistry 23.2 (2012): 192-201.
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  3. Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
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  15. Bai, Gang, et al. “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1.” Acta Pharmacologica Sinica 29.10 (2008): 1187-1194.
  16. Rao, Sulochana B., M. Chetana, and P. Uma Devi. “< i> Centella asiatica treatment during postnatal period enhances learning and memory in mice.”Physiology & behavior 86.4 (2005): 449-457.
  17. Gupta, Y. K., and M. H. VeerendraKumar. “EFFECT OF DIFFERENT EXTRACTS OF CENTELLA ASIATICA ON COGNITION AND MARKERS OF OXIDATIVE STRESS IN RATS.” Programme & Abstracts of the Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects. 2001.
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