Reviews

Komodo Nutraceuticals Visceral Response Review

Visceral Response is a multi-mechanism fat-burner by Komodo Nutraceuticals which makes use of some well-establish fat-burning ingredients as well as a some that are lesser known (but still potentially quite effective)…

Komodo Nutraceuticals Visceral Response

FIND IT HERE

Caffeine Anhydrous

Caffeine triggers the release of Catecholamines (i.e. Noradrenaline, Adrenaline, Dopamine) which, in addition to enhancing focus and alertness, are inherently pro-lipolytic. Unfortunately, habitual Caffeine consumption tends to lead to tolerance, making it less and less effective as time goes on. That being said, Caffeine may be synergistic with other stimulants and tends to increase perceived energy, leading to more intense workouts. Visceral Response contains 150mg of Caffeine per serving which, combined with the other stimulants present in the formula may certainly contribute to fat-loss (especially in those who do not consume Caffeine regularly).

Yohimbe Extract

The primary active component of Yohimbe (Pausinystalia Yohimbe) is Yohimbine, which acts as an alpha-2 receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis. By blocking the action of this receptor Yohimbine allows for more lipolysis to occur. A 2006 study showed that while there were no increases in strength, supplementation induced fat loss in athletes (soccer players).

As previously stated, Yohimbine directly acts on alpha-2 receptor, but its fat loss capabilities may also be magnified by its ability to increase the catecholamine neurotransmitters adrenaline and noradrenaline which in turn induce lipolysis. However, its ability to increase Catecholamines may degrade fairly quickly (a few weeks), so for Yohimbine to be truly effective as a weight-loss agent, it must be combined with something that activates the beta-adrenergic receptors in the first place (i.e. caffeine and other stimulants or exercise). Visceral Response contains 45mg of Yohimbe Extract per serving, though it remains unclear the exact amount of Yohimbine present in this dose.

While Yohimbe Extract is usually standardized for Yohimbine, it also contains Rauwolscine (alpha-yohimbine) which is chemically similar in structure to Yohimbine. Because of this similarity, Rauwolscine produces similar effects, although perhaps to a milder degree. Rauwolscine, as a single ingredient, has not been studies extensively for weight-loss, so an optimal dose has not been established.

Higenamine

Higenamine, also known as Norcoclaurine acts as Beta(2)Adrenergic Agonist (same mechanism as Ephedra), meaning it stimulates the Beta(2) Adrenergic Receptors which induce lipolysis (fat burning). In addition to its fat-burning potential, Higenamine has also been demonstrated in vitro to increase acetylcholine levels, though these findings have not yet been replicated in humans. Overall, there is certainly preliminary support for Higenamine as a fat-burner and potential ergogenic aid, but because no human studies exist there is recommended effective dose. Since Higenamine acts as a Beta Receptor Agonist, it may synergistically enhance the fat-burning effects of Alpha Receptor Antagonists such as Yohimbine and Rauwolscine, though this relationship has not been the subject of any published studies thus far.

Bergenin

Bergenin, also known as Cuscutin, is a compound found in Caesalpinia digyna with a somewhat well-documented use in Ayurvedic medicine for a variety of ailments. However, in the context of Visceral Response, Bergenin has implications for fat-loss. A 1998 study from the “Journal of Natural Products” found that Bergenin was able to augment Noradrenaline-induced lipolysis in rat fat-cells, while not actually inducing lipolysis by itself. To put it simply: Bergenin does not directly burn fat, but may be able enhance the effects of the other stimulant fat-burners found the Visceral Response formula.

A 2012 study from “Fitoterapia” found that Bergenin was also able to lower blood-glucose in diabetic rats, offering a possible secondary mechanism of action by which it may ultimately contribute to weight-loss. While both of the above-mentioned studies should certainly be viewed as entirely preliminary, the results warrant further research regarding Bergenin’s potential for weight-loss in humans.

Forslean

Coleus Forskohlii is an Ayurvedic herb which has been studied (though not extensively) for its potential as a weight-loss agent/testosterone booster. The active component, Forskohlin, has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss. A 2005 study, published in the “Journal of the International Society of Sports Nutrition”, found that 25mg Forskohlin twice a day for 12 weeks was able to prevent weight gain compared to the control group in overweight women. Another 2005 study, the subjects of which were overweight men, found that the same dose (25mg) was able to favorably influence body composition (i.e. less fat, more lean mass), which corresponded with an increase in testosterone over 12 weeks. A more recent 2011 study noted a roughly 2.5% decrease in BMI after 2 months of supplementation. Ultimately, Forskohlin may certainly result in weight-loss or at the very least, prevent weight gain. These effects may be more apparent in men, as an increase in cAMP also increases testosterone, which inherently burns fat and increases lean muscle mass.

Visceral Response contains 23.75mg of Forskohlin which, when taken twice daily, will certainly induce weight-loss on it’s on (and provides a non-stimulant mechanism of doing so).

Capsiate

Capsiate is chemically related to Capsaicin, and is found alongside it in Red Pepper. A 2001 study found subjects who consumed CH-19 Sweet (containing Capsiate) had significantly higher core body temperatures and increased oxygen consumption (indicative of energy production) compared to the placebo group. These findings were in-line with yet another 2001 study, the subjects of which were mice, in which Capsiate effectively suppressed the accumulation of body-fat and increased energy metabolism.

Although Capsiate and Capsaicin are roughly equal in terms of efficacy, Capsiate may be more desirable because it is non-pungent and therefore tends to be tolerated better in oral form.

Galegine

A 2008 study, published in the “British Journal of Pharmacology”, found that Galegine was able to stimulate glucose uptake as well as inhibit Acetyl-CoA Carboxylase (ACC) in rat adipocytes (fat-cells). Acetyl-CoA Carboxylase (ACC) is an enzyme, the primary function of which is to regulate fatty acid metabolism. Though the mechanisms by which ACC controls fatty acid synthesis are quite complex, put simply, ACC activation stops fatty acids from being transported to the mitochondria (to be burned) and ultimately inhibits beta-oxidation (fat-burning).

Unfortunately, human studies are lacking so it’s tough to say whether this mechanism is as strong in humans as it is in rats. For that reason, we still view Galegine as a speculative ingredient, though the mechanism by which it MAY work certainly exists.

The Bottom Line

Visceral Response is very well formulated and is certainly one of the best fat-burners we have come across. The use of a completely transparent label makes it easy to determine that every ingredient is included at a valid, effective dose. Furthermore, unlike many fat-burners containing ingredients which share the same basic mechanism of action, the diverse selection of ingredients found in Visceral Response provide multiple mechanisms of action, essentially attacking fat from many different angles.

Still not sure which fat-burner is right for you?  Check out our Top 10 Fat-Burners List!

REFERENCES
  1. Ohnuki, Koichiro, et al. “Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice.” Bioscience, biotechnology, and biochemistry 65.12 (2001): 2735-2740.
  2. Mooney, M. H., et al. “Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice.” British journal of pharmacology153.8 (2008): 1669-1677.
  3. Han, Li-Kun, et al. “Norepinephrine-Augmenting Lipolytic Effectors from Astilbe t hunbergii Rhizomes.” Journal of natural products 61.8 (1998): 1006-1011.
  4. Kumar, Rajesh, et al. “Type 2 antidiabetic activity of bergenin from the roots of< i> Caesalpinia digyna Rottler.” Fitoterapia 83.2 (2012): 395-401.
  5. Kim, Kyung-Mi, et al. “Increase in swimming endurance capacity of mice by capsaicin-induced adrenal catecholamine secretion.” Bioscience, biotechnology, and biochemistry 61.10 (1997): 1718
  6. Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158.
  7. Sax, L. “Yohimbine does not affect fat distribution in men.” International journal of obesity 15.9 (1991): 561-565.
  8. Gurguis, George NM, Bernard J. Vitton, and Thomas W. Uhde. “Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls.” Psychiatry research 71.1 (1997): 27-39.
  9. Drew, Geoffrey M. “Effects of α-adrenoceptor agonists and antagonists on pre-and postsynaptically located α-adrenoceptors.” European journal of pharmacology 36.2 (1976): 313-320.
  10. Wright, Elizabeth E., and Evan R. Simpson. “Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists.”Journal of lipid research 22.8 (1981): 1265-1270.
  11. Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine 14.4 (2006): 289-299.
  12. Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
  13. Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
  14. Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
  15. Nojima, Hiroshi, Mari Okazaki, and Ikuko Kimura. “Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice.” Journal of Asian natural products research 2.3 (2000): 195-203.
  16. Bai, Gang, et al. “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1.” Acta Pharmacologica Sinica 29.10 (2008): 1187-1194.

2 Comments
To Top
shares