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Ultra Lean FX Review

Ultra Lean FX is a non-stimulant weight-loss supplement by BioRhythm which makes use of some effective ingredients as well as some that are not-so effective…

BioRhythm Ultra Lean FX

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L-TYROSINE AKG

Tyrosine is a non-essential amino acid which serves as a precursor to the neurotransmitters Dopamine, Norepinephrine, and Epinephrine, the three of which are collectively referred to as ‘Catecholamines’. A relatively wide body of research indicates that supplemental Tyrosine has no meaningful effect on weight-loss when used in isolation, but may provide support for other ingredients which increase Catcholamine levels (such as Caffeine). While supplemental Tyrosine cannot outright raise Catcholamine levels in the brain, it can form a pool of substrate which can be drawn from to create more Catecholamines when levels are depleted.

There is anecdotal evidence in favor of Tyrosine as a mild appetite suppressant, though this has never been proven. Ultimately, in the context of Ultra Lean FX, Tyrosine should be viewed as more of a “support” ingredient than an “active” ingredient.

FUCOXANTHIN

Fucoxanthin is a carotenoid found in certain types of seaweed which has several health implications, including some related to weight-loss. Fucoxanthin has demonstrated the ability to raise the metabolic rates of mice via increasing the activity of Uncoupling Proteins in white adipose tissue which essentially removes a step from mitochondrial respiration (energy production). A 2010 study, published in “Diabetes, Obesity, and Metabolism”, found that Fucoxanthin significantly increased the metabolic rate of human subjects, but took 16 weeks for effects to become apparent. These findings are roughly in-line with the animal studies that have been conducted and indicate that Fucoxanthin can indeed result in fat-loss over a sustained period of time at relatively low doses.

What makes Fucoxanthin intriguing is that it offers a non-stimulant route to weight-loss through an entirely different mechanism of action than traditional “fat-burners” (though it does target fat). Effective doses of Fucoxanthin range from 2-8mg and supplementation generally takes anywhere from 5-16 weeks for effects to become apparent (requires time for fat-cell saturation). Ultra Lean FX contains a hefty 15mg of Fucoxanthin which is more than enough to cause moderate weight-loss.

7-KETO DHEA

7-Keto DHEA is a non-hormonal metabolite of DHEA, lower levels of which have been noted in non-obese males as opposed to obese males, and it is alleged that 7-Keto levels are negatively correlated with obesity. A 2000 study found that 200mg 7-Keto given to subjects who were on a calorie restricted diet resulted in more weight loss than the placebo group (consuming the same diet) over an 8 week period. A 2007 study, published in “The Journal of Nutritional Biochemistry”, found that 200mg of 7-keto DHEA raised the metabolic rate of subjects on a calorie restricted diet by 1.4%, whereas the placebo group experienced a 3.9% reduction in metabolic rate (the normal reaction to calorie restriction). However the length of this particular study was only 7 days, not long enough to measure weight loss, though this provides a likely mechanism of action for the first (2000) study. Other studies have noted similar results but have included 7-Keto along several other ingredients, so definite conclusions cannot be drawn from those. Overall though, it appears 7-Keto may definitely be able to play a role in long-term weight-loss.

Ultra Lean FX contains 100mg of 7-Keto DHEA per serving, meaning two servings daily would provide a clinically effective dose, although some benefit from a lower (100mg) dose cannot be ruled out.

ASHWAGANDHA

Ashwagandha is a relatively popular herbal supplement with a long and detailed history of use in Ayurvedic medicine for a variety of ailments. The alleged benefits (some more proven than others) include: cognitive enhancement, combating anxiety, enhancing vitality, and supporting bone health. However, for the purposes of Ultra Lean FX, BioRhythm seems primarily concerned with preliminary (in vitro) evidence indicating that Ashwagandha can have a positive impact of fat-cells. Indeed, a 2008 in vitro study from “Biofactors” noted that Withaferin A (an isolated compound found in Ashwagandha) was able to kill fat-cells. Unfortunately, the dose used in this study was so high that the same effect could not realistically be achieved with oral supplementation of Ashwagandha. At this time, there is just no reliable evidence to suggest Ashwagandha can meaningfully (or even subtly) impact fat-loss in humans.

GINGER

Ginger is a very common household digestive aid, commonly prescribed by loving mothers for stomach problems. However, a 2012 pilot study from “Metabolism” found that 2 grams of Ginger consumed with a meal increased caloric expenditure for several hours following the meal in overweight men. Ginger has also been shown to increase Insulin secretion via acting as a serotonin receptor antagonist (serotonin normally suppresses insulin to some degree) in mice, though a human study using 1 gram of Ginger failed to replicate this results.

Unfortunately, Ultra Lean FX contains nowhere near the amount of Ginger used in the above mentioned study, so any thermogenic effect is likely to be negligible.

CAYENNE (CAPSAICIN)

Cayenne has become a relatively popular fat-burner additive which is generally standardized for the active compound, Capsaicin. Capsaicin has been shown to increase lipolysis (fat burning) in rats as well as humans. A 2007 study noted an increase in fat oxidation (relative to placebo) during low intensity exercise in healthy adult males who consumed 150mg of capsaicin one hour before exercise. These findings make capsaicin of interest to those looking to decrease fat without the use of stimulants and, while some supplement companies certainly overstate the efficacy of Capsaicin as it pertains to weight loss, all studies certainly indicate fat burning potential.

As stated above, efficacy has been demonstrated with 150mg of Capsaicin, which is three times the dose present in one serving of Ultra Lean FX. Given that the fat-burning effects of 150mg Capsaicin aren’t particularly potent to begin with, it’s not likely that one third that dose would yield much benefit (though it cannot be entirely ruled out).

CINNAMON EXTRACT

Cinnamon Extract is generally standardized for insulin mimetic-like compounds and to remove the harmful compound, Coumarin. Though referring to Cinnamon extract as an “insulin mimetic” may be an exaggeration, it has demonstrated the ability to lower blood glucose in several human studies, and has potentiated the effects of insulin in vitro. It is unlikely that Cinnamon Extract would significantly contribute to weight-loss in the average human, but for those will high insulin resistance, it may help keep blood-glucose in check.

THE BOTTOM LINE

Ultra Lean FX contains two ingredients which can induce weight-loss, with the rest of the ingredients either playing a supporting role or being too under-dosed to even be practically relevant. It’s unclear whether the formula is intended to be consumed once or twice a day since the 7-Keto would be more effective at two doses, but the Fucoxanthin is already way up there in terms of dosage. Ultimately, while Ultra Lean FX may definitely induce fat-loss over a longer period of time (2-4 months), similar results could be obtained from combining Fucoxantin and 7-Keto DHEA from separate sources.

References

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