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Mutant Stimutant Review

Stimutant

Stimutant is a stimulant-based fat-burner by Mutant containing which may be moderately effective assuming the right dose…

 

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Stimutant is a stimulant-based fat-burner by Mutant containing which may be moderately effective assuming the right dose…[Skip to the Bottom Line]

DICAFFEINE MALATE:

Dicaffeine Malate is a combination of Caffeine and Malic Acid, which is generally alleged to be better absorbed. of Caffeine. Theoretically, this mechanism would be similar to that of Citrulline Malate, the Malate portion of which appears to enhance absorption as well as convey its own specific benefit. However, due a complete lack of studies, animal or human, Dicaffeine Malate remains a speculative ingredient in the eyes of science, and in the context of Stimutant, we’d just consider it another source of Caffeine.

CAFFEINE:

Caffeine generally serves a key ingredient in stimulant-based fat-burners because of it’s ability to release Catecholamines (Noradrenaline, Dopamine, etc.), which induce lipolysis (fat-breakdown). Although this mechanism can certainly burn fat in the short-term, prolonged Caffeine consumption (by itself) generally results in tolerance build-up so the effects become less potent over time. This was demonstrated in a 1992 study in which 24 weeks of Caffeine intake (200mg/day) failed to induce weight-loss in humans. For this reason, for Caffeine to be an effective fat-loss agent, it must be combined with other stimulants such as Synephrine.

Mutant does not disclose the exact dose of Caffeine present in the Stimuant, but the combination of Caffeine and Dicaffeine Malate could easily bring the total Caffeine content to 200+mg.

NARINGIN:

Naringin is a polyphenol commonly found in Grapefruit and some other citrus fruits which has primarily been investigated as a fat-burning agent in multiple studies.

A 2008 study from “Phytotherapy Research” found that Naringin was able to stimulate peroxisome proliferator-activated receptors (PPAR) activity in vitro, a mechanism which can induce fat-loss via the release of Adiponectin (a protein which facilitates the breakdown of fat). These results lend credibility to the already established notion that Naringin is one of the main polyphenols responsible for the weight-loss benefits of Grapefruit, noted in several studies. Naringin has also been shown to potentiate the effects of Synephrine, but since there is no Synphrine in the Stimutant formula that doesn’t really matter much.

BETA-PEA:

As far as Phenylethylamine’s direct effects on weight loss, studies are more or less non-existent. However, PEA triggers the release of Catecholamines (Noradrenaline, Adrenaline, etc.) the general physiological reaction of which is activation of the beta-adrenergic receptors which induce the breakdown of fat to be burned.

So the mechanism by which PEA may induce weight loss is theoretically sound, just not documented. PEA has a notoriously short half-life, meaning the effects tend to fade extremely quickly. For that reason, to derive any sustainable benefit from PEA supplementation, it must be combined with a compound such as Hordenine.

HORDENINE:

Despite its escalating popularity in pre-workout and weight-loss supplements, Hordenine remains very under-researched. In vitro and animal studies indicate that its primary mechanism of action is via Momoamine Oxidase inhibition, with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself. So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines). By blocking its reuptake, Hordenine allows more Noradrenaline to remain in the synaptic space, ultimately extending/augmenting its lipolytic effects. While Mutant does not disclose the exact dose of Hordenine present in the Stimutant blend, it doesn’t take much (20-50mg), so there is no reason to suspect far less than an optimal dose.

YOHIMBE EXTRACT:

The primary active component of Yohimbe (Pausinystalia Yohimbe) is Yohimbine, which acts as an alpha-2 receptor antagonist, meaning it blocks the receptor responsible for blocking lipolysis. By blocking the action of this receptor Yohimbine allows for more lipolysis to occur.

A 2006 study showed that while there were no increases in strength, supplementation induced fat loss in athletes (soccer players). As previously stated, Yohimbine directly acts on alpha-2 receptor, but its fat loss capabilities may also be magnified by its ability to increase the catecholamine neurotransmitters adrenaline and noradrenaline which in turn induce lipolysis. However, its ability to increase Catecholamines may degrade fairly quickly (a few weeks), so for Yohimbine to be truly effective as a weight-loss agent, it must be combined with something that activates the beta-adrenergic receptors in the first place (i.e. caffeine and other stimulants or exercise).

Although Mutant does not list the exact dose of Yohimbine, just a few mg will suffice, especially in combination with other stimulant compounds which can trigger fat-loss in the first place.

PIPERINE:

Piper nigrum, also known as Black Pepper, contains Piperine. Several studies have found that black pepper extract, when combined with other supplements, has increased the absorption of those supplements (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).

THE BOTTOM LINE:

The name “Stimutant” is rather fitting for this particular formula since just about every ingredient is a stimulant of some kind or, at the very least, capable of potentiating the effects of other stimulants. While the profile is a solid one for stimulant fans, the dosing of some of the ingredients may be less than optimal. Mutant recommend gauging tolerance with just 1 serving daily before bumping it up to the 2. We’re inclined to agree that it’s wise to work your way up, but the only we could see Stimutant having a particularly noticeable impact on fat-loss is at two servings per day. Given an average of 45 cents per serving, Stimutant is priced about average compared to other strictly stimulant-base fat-burners.

REFERENCES
  1. Acheson, K. J., et al. “Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals.” The American journal of clinical nutrition 33.5 (1980): 989-997.
  2. Astrup, Arne, et al. “The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial.” International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity 16.4 (1992): 269-277.
  3. Liu, Li, et al. “Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up‐regulate transcription of adiponectin.” Phytotherapy Research22.10 (2008): 1400-1403.
  4. Barwell, C. J., et al. “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat.” Journal of pharmacy and pharmacology41.6 (1989): 421-423.
  5. Sax, L. “Yohimbine does not affect fat distribution in men.” International journal of obesity 15.9 (1991): 561-565.
  6. Wright, Elizabeth E., and Evan R. Simpson. “Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists.”Journal of lipid research 22.8 (1981): 1265-1270.
  7. Drew, Geoffrey M. “Effects of α-adrenoceptor agonists and antagonists on pre-and postsynaptically located α-adrenoceptors.” European journal of pharmacology 36.2 (1976): 313-320.
  8. Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine 14.4 (2006): 289-299.
  9. Gurguis, George NM, Bernard J. Vitton, and Thomas W. Uhde. “Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls.” Psychiatry research 71.1 (1997): 27-39.
  10. Badmaev, Vladimir, Muhammed Majeed, and Lakshmi Prakash. “Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation.” The Journal of Nutritional Biochemistry 11.2 (2000): 109-113.
  11. Majeed, Muhammed, and Lakshmi Prakash. “Targeting Optimal Nutrient Absorption with Phytonutrients.” (2007)

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