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Genomyx Stimaholic Review

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STIMaholic, as the name implies, is a stimulant-based pre-workout by Genomyx meant for those individuals who want intense mental stimulation…

 

STIMaholic, as the name implies, is a stimulant-based pre-workout by Genomyx meant for those individuals who want intense mental stimulation…[Skip to the Bottom Line]

BETA-ALANINE:

Beta-Alanine is a precursor to the amino acid Carnosine, which functions as a lactic acid buffer capable of reducing fatigue in the working muscle. Though it takes time to accumulate in muscle tissue, Beta-Alanine supplementation, for at least two weeks, is highly effective at increasing muscular Carnosine concentration.

One study in particular that measured the Carnosine levels of sprinters found that individuals with higher muscular Carnosine levels exhibited higher power output in the latter half of a 30m sprint (because they had less lactic acid build-up). Multiple studies have confirmed that Beta Alanine supplementation increases muscular Carnosine in a dose dependent manner. In particular, a 2012 study published in “Amino Acids” found that subjects who consumed 1.6 or 3.2 grams of Beta Alanine daily experienced significant increases in muscle Carnosine in as little as two weeks, with the higher dose achieving a higher concentration of Carnosine. The doses used in this study, 1.6 and 3.2g, are the most common doses seen in supplements.

A 2008 study, published in the International Journal of Sports Medicine, noted improvements in power in resistance trained males using 4.8g daily for 30 days. This same 4.8 gram dose was also shown to increase muscular endurance in sprinters in a 2007 study from the “Journal of Applied Physiology”.

Although Genomyx does not disclose the exact dose of Beta-Alanine present in the STIMaholic formula, given an 1827.5mg proprietary blend, we’d estimate anwhere from 1000-1600mg, the higher end of which would be a technically effective dose.

CAFFEINE ANHYDROUS:

Caffeine is a well-established ergogenic aid, oral consumption of which triggers the release of Catcholamines (Noradrenaline, Dopamine, Adrenaline, etc.), generally inducing a state of increased alertness, focus, and perceived energy. Many studies have concluded that pre-workout Caffeine consumption can enhance exercise capacity and muscle contractibility, in many cases quite significantly.

It should be kept in mind that habitual Caffeine consumption often results in tolerance, reducing the stimulant effects. We generally recommend that individuals seeking the full benefit of pre-workout Caffeine consumption try to limit their Caffeine intake at other times of the day.

Unfortunately, Genomyx doesn’t disclose the exact dose of Caffeine in the STIMaholic formula, but we estimate anywhere from 100 to 200mg per serving. Given that STIMaholic contains several other stimulants, the formula does not appear to be entirely dependent on Caffeine.

DENDROBIUM (1% ALKALOIDS):

Dendrobium, made popular by its inclusion in DS Craze, has become relatively pervasive in the pre-workout/fat-burner category because of its alleged stimulant properties. The original claim was that Dendrobium contained several Phenylethylamine alkaloids which were responsible for the focus and mood enhancement being reported by many users. However, studies investigating the chemical constituents have failed to isolate Phenylethylamine, and have shown that different species of Dendrobium tend to vary considerably in terms of their alkaloid composition. Ultimately, the jury is still out on Dendrobium, though rat studies have confirmed some cognitive benefit which may underlie some of the subjective reports of mental stimulation and enhanced focus.

HORDENINE:

Despite its escalating popularity in pre-workout and weight-loss supplements, Hordenine remains very under-researched. In vitro and animal studies indicate that its primary mechanism of action is via Momoamine Oxidase inhibition (similar to Tyramine) with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself. So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines). By blocking its reuptake, Hordenine allows more Noradrenaline to remain in the synaptic space, ultimately extending/augmenting its effects (i.e. focus, intensity, lipolysis). The amount of Hordenine in the STIMaholic formula remains unclear, but it doesn’t take much (25-50mg) to drastically potentiate the effects of stimulants such as Caffeine and PEA, so lack of a sufficient dose is unlikely with Hordenine.

BETA-PHENYLETHYLAMINE HCL:

Phenylethylamine HCl can induce a short, but somewhat potent release of Catecholamines (Dopamine, Adrenaline, Noradrenaline). While studies testing the effects of PEA supplementation on exercise performance are limited, a boost in Catecholamines may certainly translate into more energy in the gym, resulting in a more intense workout. Unfortunately, the effects of PEA tend to degrade very quickly as it is rapidly metabolized upon reaching the brain. For this reason, it is generally seen alongside Monoamine Reuptake Inhibitors (such as Hordenine) which block the enzymes that break down PEA. Given that STIMaholic also contains Hordenine, PEA may be pretty an effective addition to the formula.

ALPHA GPC:

a-glycerophosphocholine (Alpha GPC) is considered the most bioavailable form of Choline and is often used as a cognitive enhancer. A 2010 study, published in the “Journal of the International Society of Sports Nutrition”, found that a combination of Alpha-GPC and several other ingredients was able to increase reaction time in healthy college-aged subjects, but of course this study was confounded with the inclusion of other compounds aside from just Alpha-GPC. Elsewhere, and using a much higher dose (600mg) than what is likely present in STIMaholic, Alpha-GPC was shown to increase power output when taken prior to exercise.

While Alpha-GPC does certainly have implications for cognitive and performance enhancement, it’s difficult to gauge its efficacy in the STIMaholic formula because Genomyx does not disclose the exact dose.

RAUWOLFIA VOMITORIA ROOT EXTRACT (STD. MIN. 90% RAUWOLSCINE):

Rauwolscine (also known as alpha-yohimbine) is what is known as a ‘stereoisomer’ of Yohimbine, meaning it is chemically similar in structure. Because of this similarity, Rauwolscine produces similar effects, although perhaps to a milder degree. In the context of the Nitramine formula, Rauwolscine functions as an Alpha-Receptor Antagonist which may enhance the fat-burning induced by the other stimulants (Beta-Receptor Agonists) in the formula. For individuals who do not regularly consume Rauwolscine, it may also increase focus/intensity/perceived energy via release of noradrenaline.

HUPERZINE A:

Huperzine A is an Acetylcholinesterase inhibitor which means it blocks the enzyme that breaks down the neurotransmitter acetylcholine, resulting in increased levels of acetylcholine. Acetylcholine controls skeletal muscle and is largely responsible for the ‘mind-muscle connection’. In addition to controlling the muscles, acetylcholine is also involved in learning, memory, decision making, and various other mental activities. While Huperzine is not a stimulant, it acts as more of a support ingredient in the STIMaholic formula and may enhance the efficacy of the Alpha GPC also present.

THE BOTTOM LINE:

STIMaholic is very comprehensive stimulant-based pre-workout formula, designed to appeal to those who seek enhanced focus, mood, drive, etc. Genomyx has also added a few “support” ingredients such as Alpha GPC and Huperzine A (both non-stimulant cholinergic compounds), as well as Beta-Alanine (although the dose is unknown). If stimulants are your thing, STIMaholic is definitely worth a shot as it contains just about every stimulant you might normally find in a pre-workout combined into one concentrated formula.

FIND STIMAHOLIC

REFERENCES
  1. Derave, Wim, et al. “β-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters.” Journal of applied physiology 103.5 (2007): 1736-1743.
  2. Hoffman J, et al. Beta-alanine and the hormonal response to exercise. Int J Sports Med. (2008)
  3. Stellingwerff, Trent, et al. “Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout.” Amino Acids 42.6 (2012): 2461-2472.
  4. Wilson, Jacob M., et al. “Beta-alanine supplementation improves aerobic and anaerobic indices of performance.” Strength & Conditioning Journal 32.1 (2010): 71-78.
  5. Sale, Craig, Bryan Saunders, and Roger C. Harris. “Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance.” Amino acids 39.2 (2010): 321-333.
  6. Suzuki, Yasuhiro, Osamu Ito, Naoki Mukai, Hideyuki Takahashi, and Kaoru Takamatsu. “High Level of Skeletal Muscle Carnosine Contributes to the Latter Half of Exercise Performance during 30-s Maximal Cycle Ergometer Sprinting.” The Japanese Journal of Physiology 52.2 (2002): 199-205.
  7. Graham, T. E., and L. L. Spriet. “Metabolic, catecholamine, and exercise performance responses to various doses of caffeine.” Journal of Applied Physiology 78.3 (1995): 867-874.
  8. Graham, Terry E. “Caffeine and exercise.” Sports medicine 31.11 (2001): 785-807.
  9. Barwell, C. J., et al. “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat.” Journal of pharmacy and pharmacology41.6 (1989): 421-423.
  10. Barwell, C. J., et al. “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat.” Journal of pharmacy and pharmacology41.6 (1989): 421-423.
  11. Hoffman, Jay R., et al. “The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students.” Journal of the International Society of Sports Nutrition 7.1 (2010): 39.

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