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Red Acid Reborn Review

Red Acid Reborn

Red Acid Reborn is Controlled Labs’ sequel to the brand’s original fat-burner, Red Acid. The formula is relatively simple with only five ingredients, most of which are stimulants…

 

Red Acid Reborn is Controlled Labs’ sequel to the brand’s original fat-burner, Red Acid. The formula is relatively simple with only five ingredients, most of which are stimulants…[Skip to the Bottom Line]

GREEN COFFEE EXTRACT:

Green Coffee Extract is generally standardized for Chlorogenic Acid.

A 2010 study from “Food and Chemical Toxicology” found multiple anti-obesity effects of Chlorogenic Acid administered to mice including increase beta-oxidations. However, Chlorogenic Acid may also have an alternative mechanism of action via inhibition of carbohydrate absorption.

A 2007 study, published in the “Journal of International Medical Research”, found that 12 weeks of Green Coffee (yielding 450-500mg Clorogenic Acid) supplementation resulted in a reduction (6.9%) in glucose absorption in healthy volunteers. Researchers also noted average weight loss of 5.4 kg (almost 12 lbs) over the duration of the study in the group receiving the Green Coffee Extract.

These findings conflict with an earlier 2006 study in which Green Coffee Extract (yielding 140mg Chlorogenic Acid) supplementation did not result in weight loss over the same 12 week period.

The obvious difference between these two studies is that the dose of the first (positive) study was about 3 times the dose used in the second (negative) study. A 2012 study found that adults who consumed GCE (containing about 315mg Chlorogenic Acid) daily lost an average of 8kg with the average reduction in body fat being about 4%. Though GCE has shown mixed results in various studies, efficacy has been demonstrated using higher doses. Unfortunately, GCE

NATURAL CAFFEINE:

Caffeine triggers the release of Catecholamines (i.e. Noradrenaline, Adrenaline, Dopamine) which, in addition to enhancing focus and alertness, are inherently pro-lipolytic. Unfortunately, habitual Caffeine consumption tends to lead to tolerance, making it less and less effective as time goes on. That being said, Caffeine may be synergistic with other stimulants and tends to increase perceived energy, leading to more intense workouts. Red Acid contains 100mg of (Natural) Caffeine which is towards the lower end of what is commonly found in stimulant-containing fat-burners, but may potentiate the effects of other stimulants such as Higenamine and Rauwolscine.

SYZYGIUM AROMATICUM:

Syzygium Aromaticum, more commonly known as Clove, has a somewhat well documented history of use as an aphrodisiac in traditional medicine, though there is limited research regarding this application. A 2003 study, published in “BMC Complementary and Alternative Medicine”, found that 500mg/kg of Clove extract increased sexual behavior (i.e. mounting) in male rats, though significantly less than the reference drug, Viagra. These findings where replicated in a later (2004) study in which 100-500mg/kg for 7 days enhanced the libido of otherwise healthy rats, though still significantly less than Viagra.

Ultimately, oral supplementation of Clove extract does appear to have some libido enhancement potential, but without human trials it’s difficult to draw conclusions. Furthermore, the low dose used in the second study (100mg/kg) is far more than what could possibly be present in the 690mg proprietary blend of Red Acid Reborn, so we’re not so convinced that Clove really conveys any practical benefit in the context of this particular formula.

NELUMBO NUCIFERA (HIGENAMINE):

Higenamine, commonly reffered to as Norcoclaurine, is the active compound found in Nelumbo Nucifera and has gained some traction in the supplement industry as a stimulant fat-burner because of the chemical similarities it shares with ephedrine (now banned). Like Ephedrine, Higenamine acts as Beta(2)adrenergic agonist, meaning it stimulates the beta(2) adrenergic receptors which induce lipolysis (fat breakdown). In addition to its fat-burning potential, Higenamine has also been demonstrated in vitro to increase acetylcholine levels, though these findings have not yet been replicated in humans. Overall, there is certainly preliminary support for Higenamine as a fat-burner and potential ergogenic aid, but because no human studies exist there is no recommended effective dose.

RAUWOLFIA CANESCENS:

Rauwolfia Canescens is generally standardized for Rauwolscine (also known as alpha-yohimbine) which is a ‘stereoisomer’ of Yohimbine, meaning it is chemically similar in structure. Like Yohimbine, Rauwolscine is an Alpha Receptor Antagonist, meaning it blocks the receptors responsible for blocking lipolysis. By blocking these receptors, Rauwolscine is able to potentiate the effects of other stimulant fat-burners and allow more fat-burning than would normally occur. However, since Rauwolscine generally appears alongside Yohimbine, it hasn’t been studied much in isolation, so an optimal dose has not been established.

THE BOTTOM LINE:

Despite the claims of being a “huge step forward in the evolution of fat-burners”, the Red Acid Reborn formula is not particularly impressive. While it does have some potential for burning fat, it can be mostly be attributed to the stimulants (Caffeine, Higenamine, and Rauwolscine). While we can’t be sure the exact amount of Green Coffee Extract present in the Red Acid Reborn formula, given a 690mg proprietary blend there likely isn’t a scientifically validated dose. At about 55 cents per serving, Red Acid is somewhat competitively priced, though we wouldn’t exactly consider it a bargain.

REFERENCES
  1. Watanabe, Takuya, et al. “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.”Clinical and experimental hypertension 28.5 (2006): 439-449.
  2. Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” Journal of International Medical Research 35.6 (2007): 900-908.
  3. Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
  4. Graham, T. E., and L. L. Spriet. “Metabolic, catecholamine, and exercise performance responses to various doses of caffeine.” Journal of Applied Physiology 78.3 (1995): 867-874.
  5. Graham, Terry E. “Caffeine and exercise.” Sports medicine 31.11 (2001): 785-807.
  6. Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158.
  7. Ahmad, Shamshad, Abdul Latif, and Iqbal A. Qasmi. “Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry.(clove) on sexual behaviour of normal male rats.” BMC complementary and alternative medicine 4.1 (2004): 17.
  8. Ahmad, Shamshad, Abdul Latif, and Iqbal A. Qasmi. “Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt.(nutmeg) and Syzygium aromaticum (L) Merr. & Perry.(clove) in male mice: a comparative study.” BMC Complementary and Alternative Medicine 3.1 (2003): 6.
  9. Bai, Gang, et al. “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1.” Acta Pharmacologica Sinica 29.10 (2008): 1187-1194.
  10. Nojima, Hiroshi, Mari Okazaki, and Ikuko Kimura. “Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice.” Journal of Asian natural products research 2.3 (2000): 195-203.

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