Quadralean is RSP Nutrition’s non-stimulant weight-loss formula. The ingredients consists of some well-known (but not necessarily highly effective) ingredients such as CLA and Carnitine…[Skip to the Bottom Line]
Conjugated Linoleic Acid is a term which refers to a group of polyunsaturated fatty acids (loosely referred to as ‘good fats’). In recent years, CLA has gained a reputation in the supplement industry as a fat burner. The theorized mechanism of action at work here is CLA’s alleged ability to bind to the Peroxisome Proliferator activated Receptor (PPAR) which, when activated, may directly induce fat loss.
CLA has been shown to induce considerable fat-loss in mice throughout multiple trials, but human studies have been inconsistent and lackluster at best. Though multiple (10) human studies have noted weight-loss with supplementation of CLA over varying periods of time (4 weeks to 1 year), the most notable of which was a 2012 study, published in “Vascular Health and Risk Management”, in which women with metabolic syndrome experienced an average bodyweight reduction of 2.68% over 30 days with the placebo group achieving 1.97%. While these results may technically be statistically significant, they are clearly nothing special. It’s also worth mentioned that this particular study used an ultra-concentrated form of CLA, not the standard CLA used in the Lean Mode formula.
While there are some studies showing (very minor) weight-loss with CLA supplementation, there are more (11) studies which have failed to do so, and even the positive studies don’t even come close to the rodent studies. One possible theory for the discrepancy is that rodents are more responsive to PPAR activation than humans, as evidenced in a 1999 review, published in “Nutrition Reviews”.
Ultimately, CLA by itself is no miracle fat-burner and likely won’t result in any noticeable weight-loss in most people. QuadraLean contains 500mg of CLA per serving, significantly less the doses which have demonstrated efficacy. Furthermore, given that its mechanism of action is completely separate from those of the other ingredients in the formula, there is no reason to suspect any synergy either. So, in the context of QuadraLean, CLA is pretty much useless.
GARCINIA CAMBOGIA EXTRACT:
The primary bioactive in Garcinia Cambogia is Hydroxycitric Acid (HCA), which is alleged to reduce body weight via inhibition of ATP Citrate Lysase, an enzyme required for the synthesis of fatty acids from carbohydrates (de novo lipogenisis). Theoretically speaking, blocking this enzyme would essentially stop excess carbs from being stored as fat. While inhibition of ATP Citrate Lysase has resulted in weight-loss in rodents, the implications for humans are less promising, because de novo lipogenesis occurs less in humans than rodents. Garcinia Cambogia has produced mixed results in humans.
A 1998 placebo controlled study found that 1500mg HCA daily failed to reduce bodyweight to a significantly greater degree than the placebo group.
A 2000 study, published in “Physiology & Behavior”, found that Garcinia Cambogia (1200mg HCA daily) significantly reduced bodyweight over a 12 week period compared to the placebo group.
However, a 2011 study found that 10 weeks of supplementation with 2 grams Garcinia Cambogia Extract (60% HCA) failed to reduce weight in overweight subjects, compared to placebo group.
So out of the human studies, 2 have failed and 1 has demonstrated efficacy using the same dose as one of the failed studies. Clearly these results are difficult to interpret, and there are no valid explanations for this discrepancy at this time.
Because of the popularity Garcinia Cambogia has gained in recent years as a potential weight-loss agent, several reviews have been done which have sought to determine its efficacy based on the evidence. Every review (and there have been at least four) has concluded that, while Garcinia Cambogia may be effective in rodents, this effect does not carry over to humans. While we aren’t so quick to dismiss Garcinia Cambogia, we are inclined to agree that, when looking at all the research, it doesn’t appear to be very effective in humans.
QuadraLean contains 500mg of Garcinia Cambogia per serving, with an unknown standardization of HCA. If we assume the standard 60% HCA content, three daily servings would be needed to achieve a dose in-line with the one positive study.
Despite the popularity of Raspberry Ketone, it has never actually demonstrated any efficacy for weight-loss in actual humans and, even in rat studies, has produced lackluster results using massive concentrations.
A 2010 in vitro study found that treatment with Raspberry Ketone increased fatty acid oxidation and lipolysis in adipocytes (fat cells). However, the amount/concentration of RK used in this study is beyond what could practically be consumed in oral supplement form.
A 2005 study, seeking to determine the weight loss effects of raspberry ketone on rats fed a high fat diet, noted dose dependent anti-obesity effects using doses of .5-4 grams/kg. This would roughly correspond to a 150lb person consuming 34-130 grams daily, a highly impractical dose.
In a 2012 study, similar effects were observed in rats, though this time with a focus on fat accumulation in the liver resulting from a high fat diet. The only human study that exists grouped Raspberry Ketone in with several other popular weight-loss ingredients so the effects cannot be attributed to raspberry ketones alone.
On a molecular level, Raspberry Ketone certainly demonstrates anti-obesity effects, but the doses used to achieve these effects are far more than what the average human could practically consume.
QuadraLean contains 250mg of Raspberry Ketone which, despite being more than the average dose found in most fat-burners, is not enough to convey any meaningful weight-loss benefit. RSP Nutrition is likely just capitalizing on the “buzz” factor of this ingredient (which seems to be dying down).
3 Over-Hyped Weight Loss Supplements to Avoid
Raspberry Ketone, a molecular constituent of Raspberries, has become a popular weight-loss additive in dietary supplements. However, the evidence for raspberry ketone as a fat-burning ingredient is limited to in…[Continue Reading]
CARNITINE (ACETYL, PROPIONYL, TARTRATE):
Carnitine is an amino acid that is heavily involved with the metabolism of fat for energy. It is required for the proper transport of fatty acids in the mitochondria, where they are oxidized (burned) for energy through the process known as “beta-oxidation”. Carnitine deficiency has been shown to hinder fat-burning capacity. Because of this integral role in the fat-burning process, Carnitine supplementation is alleged to burn-fat, and while it may certainly help normalize fat-burning capacity, human studies regarding weight loss are mixed.
A 2002 study, published in “Metabolism”, found that Carnitine supplementation (1g/day) increased fatty acid oxidation rates in humans without Carnitine deficiency.
A 2004 study from the same journal found that L-Carnitine supplementation (3g/day) increased fatty acid oxidation in overweight subjects while having no effect on protein synthesis or breakdown.
However, a 2005 study, published in the “International Journal for Vitamin and Nutrition Research”, found that Carnitine supplementation failed to influence weight-loss in rats. The results of this study were in-line with an earlier (2002) study in which L-Carnitine supplementation (4g/day) failed to influence fat mass, body mass, or resting lipid utilization in moderately obese women.
A more recent (2010) study found that Carnitine supplementation did favorably influence fatty acid utilization in rats, though this study did not measure fat mass post-supplementation.
Ultimately, Carnitine does possess the mechanisms by which it “should” burn fat (via increased utilization of fatty acids), though supplementation has failed to result in fat-loss in animals and humans. The most likely reason why Carnitine has failed to induce weight-loss is that the subjects in these studies did not pair Carnitine supplementation with rigorous exercise. Remember, Carnitine’s job is to transport fatty acids into the mitochondria when necessary but, without exercise, there would be no reason for Carnitine to work over-time. By increasing the demand for fatty acid utilization, exercise may very well increase the need for Carnitine and the combination of the two may result in weight-loss. However, this is purely speculation on our part and more research is needed to confirm this hypothesis.
QuadraLean contains 500mg Carnitine from three different types, though neither of these types has shown any superiority with regards to weight-loss benefit. At two servings per day, it is possible that the Carnitine in QuadraLean might favorably influence the fat-burning environment, but any particularly noticeable weight-loss is unlikely.
THE BOTTOM LINE:
QuadraLean contains the usually non-stimulant weight-loss ingredients, some of which may be slightly (but not highly) effective. Unfortunately, RSP Nutrition has failed to dose these ingredients effectively, with none of them being in line with the clinical research. It is possible that, at multiple servings daily, QuadraLean could help facilitate some minor fat-loss, but at 44 cents per serving (88 cents per two servings), there are better options in the same price range.
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