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Platinum Garcinia Plus Review

Platinum Garcinia Plus is two ingredient weight-loss supplement consisting of Garcinia Cambogia extract and Green Coffee Extract…

MuscleTech Platinum Garcinia

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GARCINIA CAMBOGIA

The popularity of Garcinia Cambogia has skyrocketed in recent years, mostly because of the seemingly incredible claims so often attached to it. The primary bioactive in Garcinia Cambogia is Hydroxycitric Acid (HCA), which is alleged to reduce body weight via inhibition of ATP Citrate Lysase, an enzyme required for the synthesis of fatty acids from carbohydrates (de novo lipogenisis). While inhibition of this enzyme has resulted in weight-loss in rodents, the implications for humans are less promising, because de novo lipogenesis occurs less in humans than rodents.

Garcinia Cambogia has produced mixed results in humans. A 1998 placebo controlled study found that 1500mg HCA daily failed to reduce bodyweight to a significantly greater degree than the placebo group. A 2000 study, published in “Physiology & Behavior”, found that Garcinia Cambogia (1200mg HCA daily) significantly reduced bodyweight over a 12 week period compared to the placebo group. However, a 2011 study found that 10 weeks of supplementation with 2 grams Garcinia Cambogia Extract (60% HCA) failed to reduce weight in overweight subjects, compared to placebo group. So out of the human studies, 2 have failed and 1 has demonstrated efficacy using the same dose as one of the failed studies. Clearly these results are difficult to interpret, and there are no valid explanations for this discrepancy at this time.

Because of the popularity Garcinia Cambogia has gained in recent years as a potential weight-loss agent, several reviews have been done which have sought to determine its efficacy based on the evidence. Every review (and there have been at least four) has concluded that while Garcinia Cambogia may be effective in rodents, this effect does not carry over to humans. While we aren’t so quick to dismiss Garcinia Cambogia, we are inclined to agree that, when looking at all the research, it doesn’t appear to be very effective in humans.

Platinum Garcinia Plus contains 1560mg of Garcinia Cambogia standardized to 936mg HCA per serving which, despite being higher than the average Garcinia Cambogia containing supplement, is still lower than the 1200mg/day which demonstrated efficacy in the one positive study mentioned above.

GREEN COFFEE EXTRACT

Green Coffee Extract (GCE) is similar to Garcinia Cambogia in terms of mechanism of action, but it holds much more promise. GCE contains Chlorogenic Acid, which is the primary bioactive compound responsible for the weight-loss achieved in several studies.

A 2010 study from “Food and Chemical Toxicology” found multiple anti-obesity effects of Chlorogenic Acid administered to mice including increase beta-oxidations. While this mechanism of action may have been partially responsible for the significant weight-loss noted in rodents, Chlorogenic Acid has an alternative mechanism of action that applied for to humans: Inhibition of carbohydrate absorption.

A 2007 study, published in the “Journal of International Medical Research”, found that 12 weeks of Green Coffee (450-500mg Clorogenic Acid) supplementation resulted in a reduction (6.9%) in glucose absorption in healthy volunteers. Researchers also noted average weight loss of 5.4 kg (almost 12 lbs) over the duration of the study in the group receiving the Green Coffee Extract. These findings conflict with an earlier 2006 study in which Green Coffee Extract (yielding 140mg Chlorogenic Acid) supplementation did not result in weight loss over the same 12 week period. The obvious difference between these two studies is that the dose of the first (positive) study was about 3 times the dose used in the second (negative) study. A 2012 study found that adults who consumed GCE (containing about 315mg Chlorogenic Acid) daily lost an average of 8kg with the average reduction in body fat being about 4%. Though GCE has shown mixed results in various studies, clear efficacy has been demonstrated at high enough doses (at least 300mg Chlorogenic Acid).

Platinum Garcinia Plus contains 200mg of GCE standardized to 90mg Chlorgenic Acid, far less than the minimum effective dose according to the research. Even at double the dosage, Platinum Garcinia Plus would still far short.

THE BOTTOM LINE

The issue with Platinum Garcinia Plus is two-fold. First, Garcinia Cambogia has a spotty track record in general, with only one out of two studies demonstrating efficacy in humans. Green Coffee Extract, on the other hand, can be a pretty effective non-stimulant weight-loss supplement when used at the right doses. This brings us to problem number two: Both Garcinia Cambogia and Green Coffee Extract are under-dosed pretty significantly. Since Garcinia Cambogia is questionable anyway, the formula really falls apart with a sub-standard dose of Green Coffee Extract, and ultimately this is why we simply cannot recommend Platinum Garcinia Plus as an effective non-stimulant weight-loss solution.

Still not sure which weight-loss supplement is right for you? Check out our Top 10 Fat-Burners List!

References

  1. Watanabe, Takuya, et al. “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.”Clinical and experimental hypertension 28.5 (2006): 439-449.
  2. Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” Journal of International Medical Research 35.6 (2007): 900-908.
  3. Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
  4. Heymsfield, Steven B., et al. “Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial.” Jama 280.18 (1998): 1596-1600.
  5. Egras, Amy M., et al. “An evidence-based review of fat modifying supplemental weight loss products.” Journal of obesity 2011 (2010).
  6. Watson, John A., and John M. Lowenstein. “Citrate and the Conversion of Carbohydrate into Fat FATTY ACID SYNTHESIS BY A COMBINATION OF CYTOPLASM AND MITOCHONDRIA.” Journal of Biological Chemistry 245.22 (1970): 5993-6002.
  7. Kim, Ji-Eun, et al. “Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial.” Nutrition journal 10.1 (2011): 94.
  8. Mattes, Richard D., and Leslie Bormann. “Effects of (−)-hydroxycitric acid on appetitive variables.” Physiology & behavior 71.1 (2000): 87-94.
  9. Egras, Amy M., et al. “An evidence-based review of fat modifying supplemental weight loss products.” Journal of obesity 2011 (2010).
  10. Lowenstein, John M. “Effect of (—)-hydroxycitrate on fatty acid synthesis by rat liver in vivo.” Journal of Biological Chemistry 246.3 (1971): 629-632.
  11. Hellerstein, Marc K. “No common energy currency: de novo lipogenesis as the road less traveled.” The American journal of clinical nutrition 74.6 (2001): 707-708.

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