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EVLution Nutrition LeanMode: An Evidence-Based Review

LeanMode is EVLution Nutrition’s stimulant-free weight loss formula which features several well-known (but not necessarily effective) weight-loss ingredients…

EVLution Nutrition LeanMode

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Garcinia Cambogia

The primary bioactive in Garcinia Cambogia is Hydroxycitric Acid (HCA), which is alleged to reduce body weight via inhibition of ATP Citrate Lysase, an enzyme required for the synthesis of fatty acids from carbohydrates (de novo lipogenisis). Theoretically speaking, blocking this enzyme would stop excess carbs from being stored as fat. While inhibition of ATP Citrate Lysase has resulted in weight-loss in rodents, the implications for humans are less promising, because de novo lipogenesis occurs less in humans than rodents. Garcinia Cambogia has produced mixed results in humans.

A 1998 placebo controlled study found that 1500mg HCA daily failed to reduce bodyweight to a significantly greater degree than the placebo group.

A 2000 study, published in “Physiology & Behavior”, found that Garcinia Cambogia (1200mg HCA daily) significantly reduced bodyweight over a 12 week period compared to the placebo group.

However, a 2011 study found that 10 weeks of supplementation with 2 grams Garcinia Cambogia Extract (60% HCA) failed to reduce weight in overweight subjects, compared to placebo group.

So out of the human studies, 2 have failed and 1 has demonstrated efficacy using the same dose as one of the failed studies. Clearly these results are difficult to interpret, and there are no valid explanations for this discrepancy at this time.

Because of the popularity Garcinia Cambogia has gained in recent years as a potential weight-loss agent, several reviews have been done which have sought to determine its efficacy based on the evidence. Every review (and there have been at least four) has concluded that, while Garcinia Cambogia may be effective in rodents, this effect does not carry over to humans. While we aren’t so quick to dismiss Garcinia Cambogia, we are inclined to agree that, when looking at all the research, it doesn’t appear to be very effective in humans.

LeanMode contains 500mg of Garcinia Cambogia (per serving) standardized to (60%) 300mg HCA so to achieve a dose in-line with the one positive human study, four servings must be consumed daily.

Green Coffee Extract

Green Coffee Extract (GCE) is similar to Garcinia Cambogia in terms of mechanism of action, but it holds much more promise. GCE contains Chlorogenic Acid, which is the primary bioactive compound responsible for the weight-loss achieved in several studies.

 

Preliminary studies indicate that Chlorogenic Acid is capable of reducing Carbohydrate absorption and initial human data supported this for the most part.  However, one of the main studies commonly cited for Green Coffee Extract was retracted due to industry influence and structural flaws.  You can learn more about that here.

In the context of LeanMode, Green Coffee Extract may be somewhat useful but it’s certainly not going to induce major weight-loss.

Conjugated Linoleic Acid

Conjugated Linoleic Acid is a term which refers to a group of polyunsaturated fatty acids (loosely referred to as ‘good fats’). In recent years, CLA has gained a reputation in the supplement industry as a fat burner. The theorized mechanism of action at work here is CLA’s alleged ability to bind to the Peroxisome Proliferator activated Receptor (PPAR) which, when activated, may directly induce fat loss.

CLA has been shown to induce considerable fat-loss in mice throughout multiple trials, but human studies have been inconsistent and lackluster at best. Though multiple (10) human studies have noted weight-loss with supplementation of CLA over varying periods of time (4 weeks to 1 year), the most notable of which was a 2012 study, published in “Vascular Health and Risk Management”, in which women with metabolic syndrome experienced an average bodyweight reduction of 2.68% over 30 days with the placebo group achieving 1.97%.

While these results may technically be statistically significant, they are clearly nothing special. It’s also worth mentioned that this particular study used an ultra-concentrated form of CLA, not the standard CLA used in the LeanMode formula.

 

We discuss why CLA isn’t all it’s cracked up to be in this article:

Conjugated Linoleic Acid: A Waste Of Time And Money?

As an ingredient in LeanMode, CLA may have some minor befefits but, like the other ingredients, it’s nothing too effective.

Acetyl-L-Carnitine

Carnitine is an amino acid that is heavily involved with the metabolism of fat for energy. It is required for the proper transport of fatty acids in the mitochondria, where they are oxidized (burned) for energy through the process known as “beta-oxidation”. Carnitine deficiency has been shown to hinder fat-burning capacity. Because of this integral role in the fat-burning process, Carnitine supplementation is alleged to burn-fat, and while it may certainly help normalize fat-burning capacity, human studies regarding weight loss are mixed.

 

Carnitine has been shown to favorably enhance the fat-burning process in instance of deficiency, but it’s not particularly effective as a weight-loss supplement in humans who aren’t deficient.

LeanMode contains 500mg of Acetyl-L-Carnitine per serving which is not a very hefty dose, though it may increase fatty acid oxidation rates with at least two servings per day.

Green Tea Extract

Multiple studies have confirmed Green Tea Extract can influence fat-loss to a statistically significant degree. Although this effect was originally thought to be related to caffeine content, more recent research has pointed to a green tea catechin known as Epigallocatechin gallate (EGCG) as the compound primarily responsible for these effects.

A 2009 study, published in “The Journal of Nutrition”, found that subjects consuming 625mg Green Tea Catechins (EGCG) alongside 40mg Caffeine paired with exercise lost an average of 2.2kg (4.8lbs) compared to the subjects in the control group (consuming just Caffeine), who lost an average of 1kg (2.2lbs). These findings were corroborated by a 2009 meta-analysis, published in the “International Journal of Obesity”, which concluded that Green Tea extract tended to cause about 1.2kg (2.6lbs) reduction in bodyweight, and that effects could be amplified with Caffeine in non-caffeine tolerant individuals.

Further research has revealed that EGCG can effectively block Catechol-o-Methyl Transferase (COMT), the enzyme responsible for the degradation of Catcholamines such as Noradrenaline. The result is an indirect increase in Noradrenaline which induces lipolysis. So, while EGCG is not likely to induce noticeable weight-loss alone, when combined with Caffeine or other Noradrenaline-releasing stimulants, it can be quite synergistic. Most of the efficacy has been demonstrated using doses of 400-500mg EGCG daily, and the less caffeine-tolerant the individual, the better.

LeanMode contains 250mg Green Tea Extract per serving, standardized to 150mg (60%) EGCG. At three servings per day, this is technically within the effective range.

The Bottom Line

Some of the ingredient in LeanMode may cause some minor weight-loss in the long-term, but nothing in it is particularly effective in the short-term.  Don’t expect any sort of rapid weight-loss with this formula, but if you take it consistently for months, it may help drop a few pounds.

If you’re interested in a fat-burner that will work much faster, check out our Top 10 Fat-Burners List!

Supplement Facts

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  21. Gaullier, Jean-Michel, et al. “Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans.” The American journal of clinical nutrition 79.6 (2004): 1118-1125.
  22. Thom, E., Jan Wadstein, and O. Gudmundsen. “Conjugated linoleic acid reduces body fat in healthy exercising humans.” Journal of International Medical Research 29.5 (2001): 392-396.
  23. Carvalho, Roberta F., Sofia K. Uehara, and Glorimar Rosa. “Microencapsulated conjugated linoleic acid associated with hypocaloric diet reduces body fat in sedentary women with metabolic syndrome.” Vascular health and risk management 8 (2012): 661.
  24. Wutzke, Klaus D., and Henrik Lorenz. “The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects.”Metabolism 53.8 (2004): 1002-1006
  25. Seim, H., W. Kiess, and T. Richter. “Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults.” Metabolism 51.11 (2002): 1389-1391.
  26. Melton, S. A., et al. “L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.” International journal for vitamin and nutrition research 75.2 (2005): 156-160.
  27. Villani, Rudolph G., et al. “L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.”International journal of sport nutrition and exercise metabolism 10.2 (2000): 199-207.
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