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Hydroxycut SX-7 Review

Hydroxycut SX-7

Hydroxycut SX-7 is a relatively new addition to the MuscleTech lineup which features a variety of rare ingredients, most of which have very little research regarding the weight-loss implications. Still, the formula as a whole may be moderately effective…

 

Hydroxycut SX-7 is a relatively new addition to the MuscleTech lineup which features a variety of rare ingredients, most of which have very little research regarding the weight-loss implications. Still, the formula as a whole may be moderately effective…[Skip to the Bottom Line]

GREEN COFEE EXTRACT:

A 2010 study from “Food and Chemical Toxicology” found noted multiple anti-obesity effects of Chlorogenic Acid administered to mice including increase beta-oxidations. However, Chlorogenic Acid may also have an alternative mechanism of action via inhibition of carbohydrate absorption.

A 2007 study, published in the “Journal of International Medical Research”, found that 12 weeks of Green Coffee (yielding 450-500mg Clorogenic Acid) supplementation resulted in a reduction (6.9%) in glucose absorption in healthy volunteers. Researchers also noted average weight loss of 5.4 kg (almost 12 lbs) over the duration of the study in the group receiving the Green Coffee Extract.

These findings conflict with an earlier 2006 study in which Green Coffee Extract (yielding 140mg Chlorogenic Acid) supplementation did not result in weight loss over the same 12 week period. The obvious difference between these two studies is that the dose of the first (positive) study was about 3 times the dose used in the second (negative) study.

A 2012 study found that adults who consumed GCE (containing about 315mg Chlorogenic Acid) daily lost an average of 8kg with the average reduction in body fat being about 4%. Though GCE has shown mixed results in various studies, efficacy has been demonstrated using higher doses.

Hydroxycut SX-7 contains 400mg GCE yielding about 180mg of Chlorogenic Acid. Although this is significantly less than the scientifically validated dose of around 300mg, the inclusion of Sage Leaf Extract (also containing Chlorogenic Acid) may help potentiate the effects.

CAFFEINE:

Caffeine is the most widely consumed psychoactive substance in the world, and is a well-established ergogenic aid. Caffeine consumption causes an increase in Catecholamines (Adrenaline, Noradrenaline, and Dopamine), which tend to increase focus, concentration, and perceived energy while simultaneously promoting fat oxidation.

However, the weight loss effects of caffeine tend to fade with prolonged use, so it does not appear as though caffeine is a long-term effective fat burner. While caffeine’s weight loss potential is negligible, it increases focus and perceived energy in most people, which generally leads to more intense workouts (thus burning more fat), and may potentiate the action of other stimulants like yohimbine. At 135mg per serving, the formula is certainly not overly dependent on caffeine and leaves the option for multiple servings.

SALVIA OFFICINALIS:

Sage Leaf contains, among other things Chlorogenic Acid. So, in the context of Hydroxcut SX-7, it is essentially the same as Green Coffee Extract.

MYRISTICA FRAGRANS:

Myristica fragrans seed extract, also known as Nutmeg, is common household spice which is generally used in small amounts. However, larger doses of Nutmeg can have psychoactive effects. Nutmeg contains myristicin, which has been demonstrated to act as a monoamine oxidase inhibitor in mice. By inhibiting Monoamine Oxidase, levels of monoamine neurotransmitters (such as Noradrenaline) may remain elevated for longer, which theoretically would increase lipolysis. However, the practical effects of Nutmeg as a weight loss agent have not been studied in either animals or humans so for now we are left only with a theoretical mechanism of action.

RASPBERRY KETONE:

Raspberry Ketone, a molecular constituent of Raspberries, have become a popular weight-loss additive in dietary supplements. However, the evidence for raspberry ketone as a fat-burning ingredient is extremely limited and there is actually no direct evidence the ingredient is effective in oral, supplemental doses. In vitro studies using very high concentrations have shown positive results, but human studies are non-existent. The only human study that exists grouped RK in with several other popular weight loss ingredients so the effects cannot be attributed to raspberry ketone. Even in rat studies, RK fail to show any significant fat-burning effects. The overall consensus of the scientific community is that raspberry ketone are nothing more than industry hype.

ECKLONIA CAVA:

Ecklonia cava is a type of brown seaweed containing antioxidant compounds called phloroglucinols, alleged to convey weight loss benefits. Only one human study has been conducted. A 2012 study, published in “Phytotherapy Research”, found that 12 weeks of supplementation with Ecklonia cava (72-144mg) polyphenols resulted in very slight weight loss (.9-1.3kg) in overweight adult subjects. A mechanism of action was not determined, nor are the results particularly significant. Most overweight individuals wouldn’t consider a couple pounds in 12 weeks a significant loss.

YOHIMBE:

The primary active component of Yohimbe (Pausinystalia Yohimbe) is Yohimbine, which acts as an alpha-2 receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis. By blocking the action of this receptor Yohimbine allows for more lipolysis to occur. A 2006 study showed that while there were no increases in strength, supplementation induced fat loss in athletes (soccer players). As previously stated, Yohimbine directly acts on alpha-2 receptor, but its fat loss capabilities may also be magnified by its ability to increase the catecholamine neurotransmitters adrenaline and noradrenaline which in turn induce lipolysis.

However, its ability to increase catcholamines may degrade fairly quickly (a few weeks), so for Yohimbine to be truly effective as a weight-loss agent, it must be combined with something that activates the beta-adrenergic receptors in the first place (i.e. caffeine and other stimulants or exercise). It’s worth mentioning that Hydroxycut SX-7 only contains around .5mg of Yohimbine, far less than the 20mg used in the above mentioned study.

RAUWOLSCINE:

Rauwolscine (also known as alpha-yohimbine) is what is known as a ‘stereoisomer’ of yohimbine, meaning it is chemically similar in structure. Because of this similarity, Rauwolscine produces similar effects, although perhaps to a milder degree. It is common for supplement companies to include both Rauwolscine and Yohimbine together since both compounds are naturally present in certain plants (Yohimbe).

THE BOTTOM LINE:

Hydroxycut SX-7 contains several ingredients found in the other Hydroxycut formulas as well as some new additions (nutmeg, sage, brown seaweed). With the exception of Raspberry Ketone and Nutmeg, all of the ingredients have shown some degree of efficacy with regards to weight loss. While individuals may have to take multiple doses depending on individual sensitivity (or lack thereof), the formula may be relatively effective as a fat-burner, especially when paired with a healthy diet and exercise.

FIND HYDROXYCUT SX-7

REFERENCES
  1. Charney, Dennis S., George R. Heninger, and D. Eugene Redmond Jr. “Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine.” Life sciences 33.1 (1983): 19-29
  2. Sax, L. “Yohimbine does not affect fat distribution in men.” International journal of obesity 15.9 (1991): 561-565.
  3. Gurguis, George NM, Bernard J. Vitton, and Thomas W. Uhde. “Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls.” Psychiatry research 71.1 (1997): 27-39.
  4. Drew, Geoffrey M. “Effects of α-adrenoceptor agonists and antagonists on pre-and postsynaptically located α-adrenoceptors.” European journal of pharmacology 36.2 (1976): 313-320.
  5. Wright, Elizabeth E., and Evan R. Simpson. “Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists.”Journal of lipid research 22.8 (1981): 1265-1270.
  6. Galitzky, J., et al. “Pharmacodynamic effects of chronic yohimbine treatment in healthy volunteers.” European journal of clinical pharmacology 39.5 (1990): 447-451.
  7. McCarty, Mark F. “Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis.”Medical hypotheses 58.6 (2002): 491-495.
  8. Galitzky, J., et al. “Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue.” Journal of Clinical Investigation 91.5 (1993): 1997.
  9. Shin, Hyeon‐Cheol, et al. “Effects of 12‐week Oral Supplementation of Ecklonia cava Polyphenols on Anthropometric and Blood Lipid Parameters in Overweight Korean Individuals: A Double‐blind Randomized Clinical Trial.” Phytotherapy research 26.3 (2012): 363-368.
  10. Truitt, Edward B., Gilbert Duritz, and Ethel M. Ebersberger. “Evidence of monoamine oxidase inhibition by myristicin and nutmeg.” Experimental Biology and Medicine 112.3 (1963): 647-650.
  11. Watanabe, Takuya, et al. “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.”Clinical and experimental hypertension 28.5 (2006): 439-449.
  12. Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” Journal of International Medical Research 35.6 (2007): 900-908.
  13. Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
  14. Wang, Lili, Xianjun Meng, and Fengqing Zhang. “Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.” Journal of medicinal food 15.5 (2012): 495-503.
  15. Park, Kyoung Sik. “Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.” Planta medica 76.15 (2010): 1654.
  16. Morimoto, Chie, et al. “Anti-obese action of raspberry ketone.” Life sciences77.2 (2005): 194-204.

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