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ANS Performance HIT Review

ANS Performance HIT

 

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HIT is a stimulant-containing, though not entirely stimulant-dependent, fat-burner from ANS Performance…[Skip to the Bottom Line]

CAFFEINE:

Caffeine triggers the release of Catecholamines (i.e. Noradrenaline, Adrenaline, Dopamine) which, in addition to enhancing focus and alertness, are inherently pro-lipolytic. Although this mechanism can certainly burn fat in the short-term, prolonged Caffeine consumption generally results in tolerance build-up so the effects become less potent over time. However, Caffeine can still increase increase focus and perceived energy resulting in improved workouts as well as amplify the effects of other stimulants. ANS does not disclose the exact amount of Caffeine present in the HIT formula, but we estimate anywhere from 100-200mg.

ELMN8™ ALCHEMILLA VULGARIS EXTRACT:

Alchemilla vulgaris, also known as Lady’s Mantle, is an herb with a somewhat limited history of use as an herbal supplement, mostly for treating stomach related issues and symptoms of menopause. It is alleged to regulate digestive enzymes, and ANS further alleges that it increases body temperature and reduces appetite. To be fair, there is no reliable human evidence for these claims.

OLIVE LEAF EXTRACT (OLEA EUROPAEA):

The primary active compound found in Olive Leaf Extract is Oleuropein, a potent phenol responsible for the extracts adrenergic effects. A 2007 study from “The Journal of Nutritional Biochemistry” demonstrated increased Noradrenaline and Adrenaline levels in rats following injection of Olive Leaf extract. Similar findings were noted in a 2013 study published from “The Journal of Nutritional Biochemistry” in which rats fed a diet high in Oleuropein experienced significantly increased Noradrenaline levels (measured in urine), though it’s worth mentioning that this was not accompanied by the usual decrease in weight. In fact, Oleuropein may actually down-regulate beta-adrenergic receptors, as evidenced in a 2012 study from “The American Journal of Clinical Nutrition” (although this was in Endothelial cells, not fat-cells). Ultimately, while Oleuropein may certainly induce Noradrenaline release , thereby increasing perceived energy and focus, the fat-burning implications for humans remain unclear.

CUMINUM CYMINUM:

Cuminum cyminum is an Ayurvedic herb which has historically been used as a digestive aid. However, preliminary research indicates supplementation may have a favorable impact on blood sugar and triglycerides. A 2002 study from “Pharmacological Research” demonstrated the ability of Cuminum Cyminum to lower blood triglycerides and increase certain pancreatic enzymes in diabetic rats. These findings were replicated in a 2005 study, also using rats, in which Cuminum Cyminum was shown to be an Aldose Reductase inhibitor.

MENTHA LONGIFOLIA:

Mentha Longifolia, also known as Mint, has a variety of implications as a supplement and home remedy for certain ailments, but is most commonly used as a digestive aid and stomach relaxant. In the context of the HIT formula, it has essentially the same function. ANS claims that Mint promotes digestion and gastic emptying, which is true, though an optimal dose has never been established for this. Overall, we certainly wouldn’t consider Mint a key ingredient, but it may contribute to the overall effect.

THEANINE:

Theanine is commonly found in Green Tea and is generally believed to be the agent in the tea that promotes relaxation and counteracts the caffeine that is also present in green tea. Multiple studies have been conducted using doses of 50-200mg and all have shown promise with regards to this synergy between Caffeine and Theanine. In the context of the HIT formula, Theanine is primary intended to convey anti-stress benefits and compliment the effects of Caffeine.

COFFEA ARABICA:

The primary active component found in Coffea Arabica is Chlorogenic Acid which has recently become a popular weight-loss option for stimulant-adverse individuals.

A 2010 study from “Food and Chemical Toxicology” found multiple anti-obesity effects of Chlorogenic Acid administered to mice including increase beta-oxidations (fat-burning). While this increase in fat-burning may have been partially responsible for the significant weight-loss noted in rodents, Chlorogenic Acid has an alternative mechanism of action that applied for to humans: Inhibition of carbohydrate absorption.

A 2007 study, published in the “Journal of International Medical Research”, found that 12 weeks of Green Coffee (450-500mg Clorogenic Acid) supplementation resulted in a reduction (6.9%) in glucose absorption in healthy volunteers. Researchers also noted average weight loss of 5.4 kg (almost 12 lbs) over the duration of the study in the group receiving the Green Coffee Extract.

A 2006 study, this time using a smaller dose of Green Coffee Extract (yielding 140mg Chlorogenic Acid), found no such weight-loss benefit over a 12 week period. The obvious difference between these two studies is that the dose of the first (positive) study was about 3 times the dose used in the second (negative) study.

A 2012 study found that adults who consumed GCE (containing about 315mg Chlorogenic Acid) daily lost an average of 8kg with the average reduction in body fat being about 4%.

It’s unclear how much Coffea Arabica is present in the HIT formula but, given its position in the 388mg proprietary blend, there is likely not an effective dose. Even at 3 servings per day, HIT may only convey a marginally effective dose of Chlorogenic Acid.

HORDENINE:

In vitro and animal studies indicate that Hordenine’s primary mechanism of action is via Momoamine Oxidase inhibition, with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself. So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines). By blocking its reuptake, Hordenine allows more Noradrenaline to remain in the synaptic space, ultimately extending/augmenting its physiological effects (i.e. lipolysis). Unfortunately, until more human research is published we won’t know exactly how potent oral doses can be, but generally speaking, Hordenine possesses clear mechanisms by which it should help burn fat.

EVODIA RUTAECARPA:

Evodiamine is a plant extract which appears to mimic the thermogenic effects of Capsaicin in rats. However, no human studies have been published at this time testing the effects of the extract on humans. Due to the lack of human studies available, we cannot determine with any considerable degree of certainty, the efficacy of Evodiamine.

SCHIZANDRA CHINESIS:

Schizandra, generally standardized for the active compound Schizandrol A, has historically been used as a performance enhancer. A 2008 study from the “Journal of Ethnopharmacology” found that Schizandra was able to increase time to fatigue in mice. Allegedly, human trials have been conducted in Russia, though these studies have not been made available in the Western world online or in hard copy. For now, we would still consider Schizandra speculative, though it may certainly act as adaptogen and help to reduce mental and physical stress.

THE BOTTOM LINE:

While HIT contains several effective weight-loss ingredients, several of these ingredients are under-dosed. ANS touts Green Coffee Extract as a major feature of HIT, and while Chlorogenic Acid (the primary bioactive in GCE) has demonstrated some clear efficacy with regards to weight-loss, the amount present in a serving of HIT is far less than what has proven effective in studies. So, any weight loss induced by HIT is likely to be caused by the stimulants (Caffeine, Hordenine, Olive Leaf Extract, etc.). At less than 30 cents a dose, HIT is certainly cost-efficient, but given the subpar doses of key ingredients, it may not be such a bargain after all.

REFERENCES
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  2. Castañer, Olga, et al. “Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans.” The American journal of clinical nutrition 95.5 (2012): 1238-1244.
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  4. Gimeno, Eva, et al. “Changes in the phenolic content of low density lipoprotein after olive oil consumption in men. A randomized crossover controlled trial.”British journal of nutrition 98.06 (2007): 1243-1250.
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  8. Lee, Hoi-Seon. “Cuminaldehyde: aldose reductase and α-glucosidase inhibitor derived from Cuminum cyminum L. seeds.” Journal of agricultural and food chemistry 53.7 (2005): 2446-2450.
  9. Mkaddem, Mounira, et al. “Chemical composition and antimicrobial and antioxidant activities of Mentha (longifolia L. and viridis) essential oils.” Journal of food science 74.7 (2009): M358-M363.
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  13. Watanabe, Takuya, et al. “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.”Clinical and experimental hypertension 28.5 (2006): 439-449.
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  16. Barwell, C. J., et al. “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat.” Journal of pharmacy and pharmacology41.6 (1989): 421-423
  17. Nedergaard, O. A., and E. Westermann. “Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea‐pig.” British journal of pharmacology 34.3 (1968): 475-483.
  18. Finberg, J. P., and Ken Gillman. “Selective inhibitors of monoamine oxidase type B and the “cheese effect”.” Int Rev Neurobiol 100 (2011): 169-90.
  19. Panossian, A. G., et al. “Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva.” Phytomedicine 6.1 (1999): 17-26.

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