1st Phorm Commander Review

1st Phorm Commander

Commander is a fat-burner by 1st Phorm which is mostly fueled by stimulants, though it does contain some non-stimulant ingredients…


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Commander is a fat-burner by 1st Phorm which is mostly fueled by stimulants, though it does contain some non-stimulant ingredients…[Skip to the Bottom Line]


1,3,7-trimethylxanthine, or Caffeine, is by far the most common ingredient among stimulant-based fat-burners because it triggers the release of Noradrenaline, a potent activator of lipolysis.

Although Caffeine possesses pro-fat-loss properties, the effects tend to fade with prolonged use, rendering it ineffective as a long-term weight loss solution on its own. However, when paired with other fat-burning stimulants (1st Phorm has placed quite a few in the Commander formula), Caffeine can kickstart the fat-burning process.

1st Phorm does not list the exact dose of Caffeine in the Commander formula, but we’d estimate 100-200mg per serving.


1st Phorm lists Picamilon as 4-(pyridine-3-carbonylamino)butanoic acid, but we’re not sure why. It’s nothing more than Picamilon.

Picamilon is formed by combining Niacin (vitamin B3) and GABA (the primary inhibitory neurotransmitter in mammals). Pikamilon is able to effectively cross the blood-brain-barrier where it is converted into GABA. Since GABA is an inhibitory neurotransmitter (as opposed to excitatory) it may produce anxiolytic effects when levels are increased beyond normal. However, Picamilon does not produce the sedative like effects of other GABA pro-drugs and instead is commonly used as a nootropic (cognitive enhancer) because it has also been demonstrated to increase cerebral blood flow due to its Niacin component (Niacin is a vasodilator).

Picamilon does not possess any known fat-burning properties but may enhance the cognitive dimension of Commander. 1st Phorm does not make any particular claims regarding Picamilon or the dose used in Commander.


Hordenine is included in many fat-burners because of its ability to amplify the effects of Caffeine. Preliminary studies indicate that its primary mechanism of action is via Momoamine Oxidase inhibition, with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself.

So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines).

1st Phorm does not list the amount of Hordenine present in Commander but it generally only takes 20-50mg to noticeably enhance the effects of Caffeine and/or other stimulants so under-dosing is not an issue here.


N-Methyl-Tyramine (NMT) is a Tyramine which, as mentioned above, can inhibit the reuptake of monoamines (specifically Noradrenaline), thereby amplifying and/or extending the effects of Noradrenaline releasing stimulants such as Caffeine.

Although 1st Phorm does not disclose the exact dose of NMT in Commander, like Hordenine, it takes just 20 or so mg to do the trick.


Cocoa Extract is generally standardized for Theobromine, a chemical relative of Caffeine but that remains seriously under-researched with regards to weight-loss potential. Preliminary studies indicate that Theobromine is a cardiac stimulant, but it does not appear to have psychoactive effects like Caffeine (i.e. energy).

1st Phorm does not list the exact amount of Cocoa Extact, but given that no optimal dose has been established in humans, it doesn’t really matter.


Huperzine A is an Acetylcholinesterase inhibitor which means it blocks the enzyme that breaks down the neurotransmitter acetylcholine, resulting in increased levels of acetylcholine. Acetylcholine controls skeletal muscle and is largely responsible for the ‘mind-muscle connection’. In addition to controlling the muscles, acetylcholine is also involved in learning, memory, decision making, and various other mental activities.

Huperzine A has no know weight-loss implications but instead may help to improve the cognitive aspect of the Commander formula. 1st Phorm does not disclose the dose but even just 50mcg would be sufficient so we’re not worried about the dose here.


Choline, once inside the body, is converted into the neurotransmitter Acetylcholine which is associated with many functions including (but not limited to) memory, attention, and muscle control.

Choline Bitartrate supplementation has been shown to reduce bodyweight while preserving strength in female Judo athletes.

1st Phorm doesn’t tell us exactly how much Choline is present in Commander, but it’s a safe bet that it’s far less than what was used in this study.


Dimethylaminoethanol, or DMAE for short, is a cholinergic compound which is generally used as a cognitive enhancement agent.  It has been shown to improve certain aspects of cognitive function in older subjects with mild cognitive impairment, but has not been studied much in healthy individuals, let alone athletes.


Sulbutiamine is an analogue (chemical relative) of Thiamine (Vitamin B1), the benefits of which pertain mostly to fatigue.

A 1999 study found that subjects suffering from chronic post-infectious fatigue who consumed 400 and 600mg of Sulbutiamine experienced significant reduction in over-all fatigue compared to the placebo group.

These findings were replicated in a 2003 study, published in “The Journal of the Association of Physicians of India”, in which subjects (again with infection-induced fatigue) who consumed 400mg reported significant reductions in fatigue as well.

Unfortunately, Sulbutiamine has yet to be studies in healthy humans, let alone athletes, so its difficult to say how much of an effect it actually has in the Commander formula. 1st Phorm makes no specific claims regarding Sulbutiamine so for now we’ll consider it more of “support” ingredient than a “key” ingredient.


Bacopa Monnieri is an herb which has traditionally been used as a nootropic and anxiolytic. However, in the context of Thermo Fire, the implied claim is that Bacopa Monnieri is able to influence Thyroid Hormones, thus positively impacting body weight.

A 2002 study from “Ethnopharmacology” found that 200mg/kg daily of Bacopa Extract was able to raise T4 (a Thryoid Hormone) by about 42% in male mice. Currently, the effects of Bacopa on Thyroid hormones have not been studied in human subjects, and it is unknown how beneficial it can be for weight loss. Logically, the most likely individuals to benefit from Bacopa supplementation would be those with Thyroid issues and abnormally low levels of T4.

Needless to say, Commander contains nowhere near the human-equivalent dose of what was used in the study above so it’s not really clear how effective Bacopa is in this particular instance.


Beta-Phenylethylamine can induce a short, but powerful release of Catecholamines (Dopamine, Adrenaline, Noradrenaline). While studies testing the effects of PEA supplementation on exercise performance are non-existent, a boost in Catecholamines may certainly translate into more energy in the gym, resulting in a more intense workout.

The direct fat-burning potential of PEA has yet to be studied in humans, though it stands to reason that it may be moderately effective via Noradrenaline release, especially when paired with Hordenine.


Green Tea has been shown to inhibit Catechol-O-Methyl Transferase (COMT), thereby extending/amplifying the effects of stimulants such as Caffeine. We discuss the fat-burning implications of Green Tea Extract more in this article.

1st Phorm does not list the exact dose of Green Tea Extract in Commander but, given a 150mg proprietary blend, it is clearly under-dosed relative to what has demonstrated efficacy in a clinical setting.


Coleus Forskohlii contains the active compound, Forskolin, which has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.

We discuss the weight-loss implications of Forskolin in this article, but it may certainly contribute to the overall efficacy of the Commander formula.

The only issue we have is with the dosing. 1st Phorm doesn’t list the exact dose but, given that Coleus Forskohlii (20% Forskolin) is listed second in a mere 150mg proprietary blend, it is clearly less than what has been used clinically for weight-loss.


Evodiamine is a plant extract which appears to mimic the thermogenic effects of Capsaicin in rats. However, no human studies have been published at this time testing the effects of the extract on humans. Due to the lack of human studies available, we cannot determine with any considerable degree of certainty, the efficacy of Evodiamine.


Cayenne contains the compound Capsaicin, which has been shown to increase in fat oxidation (relative to placebo) during low intensity exercise in healthy adult males.

Although it can be a somewhat effective fat-burning ingredient at certain doses, Commander appears under-dosed given the weight of the overall proprietary blend.


1st Phorm lists Synephrine as 4-[1-hydroxy-2-(methylamino)ethyl]phenol which may confuse some users but it’s no different than the Synephrine found in any other fat-burner.

Synephrine acts as a beta-receptor agonist, directly inducing lipolysis and allowing for more fat-burning than would otherwise normally occur.

Supplementation with 50mg has been shown to increase metabolic rate in humans without affecting blood-pressure or heart rate.

1st Phorm does not disclose the amount of Synephrine in Commander.


Green Coffee Extract contains Chlorogenic Acid which has been shown to block carbohydrate absorption in humans, thus mimicking the effects of a reduced carb-diet. We discuss Green Coffee Extract in depth in this article, but it may not be effective in the context of Commander due to severe under-dosing.


Guarana is just another source of Caffeine, so the weight-loss implications are the same as Caffeine. 1st Phorm does not disclose the amount of Guarana present in Commander.


Yohimbine acts as an alpha(2) receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis (breakdown of fat). By blocking the action of this receptor Yohimbine allows for more lipolysis than would otherwise be possible from exercise.

We discuss the fat-burning implications of Yohimbine further in this article, but it can be very effective, assuming the right dose. That said, 1st Phorm provides no clues as to how much Yohimbine is present in Commander.


Diiodotyrosine is the precursor to Thyroid Hormone. Studies regardin the weight-loss potential of Diiodotyrosine, however, are non-existent. Individuals with under-active Thyroids may stand to gain the most from Diiodotyrosine supplementation. For now we’d label this a highly speculative ingredient.


The fat-burning potential of Commander is dependent entirely on the stimulants in the formula, as the non-stimulant ingredients are all severely under-dosed on a per serving basis…Interesting considering 1st Phorm’s stance against “Pixie Dusting”. That said, because Commander does contain several potent stimulants, it may actually be pretty effective as a fat-burner at the high-end of the recommended dose (two servings twice daily). Like most 1st Phorm products, Commander is over-priced relative to competing products with similar (or better) formulas.

  1. Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158
  2. Arciero, PAUL J., et al. “Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.” American Journal of Physiology-Endocrinology And Metabolism 268.6 (1995): E1192-E1198.
  3. Astrup, A., et al. “Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers.” The American journal of clinical nutrition 51.5 (1990): 759-767
  4. Graham, Terry E., Jorn W. Helge, David A. MacLean, Bente Kiens, and Erik A. Richter. “Caffeine Ingestion Does Not Alter Carbohydrate or Fat Metabolism in Human Skeletal Muscle during Exercise.” The Journal of Physiology 529.3 (2000): 837-47
  5. Elsawy, Gehan, Osama Abdelrahman, and Amr Hamza. “Effect of choline supplementation on rapid weight loss and biochemical variables among female Taekwondo and Judo athletes.” Journal of human kinetics 40.1 (2014): 77-82.
  6. Thielecke, Frank, et al. “Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study.” European journal of clinical nutrition 64.7 (2010): 704-713.
  7. Lu, Hong, Xiaofeng Meng, and Chung S. Yang. “Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (−)-epigallocatechin gallate.” Drug metabolism and disposition 31.5 (2003): 572-579.
  8. Keränen, Tapani, et al. “Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone.” European journal of clinical pharmacology 46.2 (1994): 151-157.
  9. Brown, A. L., et al. “Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial.” British Journal of Nutrition106.12 (2011): 1880-1889.
  10. Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
  11. Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” Journal of International Medical Research 35.6 (2007): 900-908.
  12. Watanabe, Takuya, et al. “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.”Clinical and experimental hypertension 28.5 (2006): 439-449.
  13. Mirzoyan, R. S., et al. “Effect of picamilon on the cerebral cortical blood supply and microcirculation in the pial arteriolar system.” Bulletin of Experimental Biology and Medicine 107.5 (1989): 668-670.
  14. Barwell, C. J., et al. “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat.” Journal of pharmacy and pharmacology41.6 (1989): 421-423.
  15. Arciero, PAUL J., et al. “Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.” American Journal of Physiology-Endocrinology And Metabolism 268.6 (1995): E1192-E1198.
  16. hah, Siddharth N. “Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia.” The Journal of the Association of Physicians of India 51 (2003): 891-895.
  17. Tiev, K. P., J. Cabane, and J. C. Imbert. “[Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo].” La Revue de medecine interne/fondee… par la Societe nationale francaise de medecine interne 20.10 (1999):
  18. Kozikowski, Alan P., and Werner Tueckmantel. “Chemistry, pharmacology, and clinical efficacy of the Chinese nootropic agent huperzine A.” Accounts of chemical research 32.8 (1999): 641-650.
  19. Boudinot, Eliane, et al. “Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase.” Pharmacology Biochemistry and Behavior 80.1 (2005): 53-61.
  20. Dubois, Bruno, et al. “Effect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer’s disease.”Journal of Alzheimer’s Disease3 (2012): 527-535.
  21. Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
  22. Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
  23. Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
  24. Shin, Ki Ok, and Toshio Moritani. “Alterations of Autonomic Nervous Activity and Energy Metabolism by Capsaicin Ingestion during Aerobic Exercise in Healthy Men.” Journal of Nutritional Science and Vitaminology 53.2 (2007): 124-32
  25. Ohnuki, Koichiro, et al. “Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice.” Bioscience, biotechnology, and biochemistry 65.12 (2001): 2735.
  26. WATANABE, TATSUO, et al. “Adrenal sympathetic efferent nerve and catechol secretion excitation caused by capsaicin in rats.” (1988).
  27. Stohs, Sidney J., et al. “Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.” International journal of medical sciences 8.4 (2011): 295.
  28. Haaz, S., et al. “Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update.” Obesity reviews 7.1 (2006): 79-88.
  29. Kaats, Gilbert R., et al. “A 60day double-blind, placebo-controlled safety study involving< i> Citrus aurantium(bitter orange) extract.” Food and Chemical Toxicology 55 (2013): 358-362.
  30. Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine 14.4 (2006): 289-299.
  31. Balsam, A., et al. “Formation of diiodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism.” Journal of Clinical Investigation 72.4 (1983): 1234.

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